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Titolo:
STIMULATION WITH CHOLECYSTOKININ LEADS TO INCREASED RATIO BETWEEN MESSENGER-RNA LEVELS FOR ANIONIC AND CATIONIC TRYPSINOGEN IN RAT PANCREAS
Autore:
BORGSTROM A; HE XH; AXELSON J;
Indirizzi:
MALMO UNIV HOSP,DEPT SURG & SURG PATHOPHYSIOL S-20502 MALMO SWEDEN
Titolo Testata:
Journal of gastroenterology
fascicolo: 6, volume: 32, anno: 1997,
pagine: 797 - 800
SICI:
0944-1174(1997)32:6<797:SWCLTI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-SEQUENCES; SERUM; CDNAS;
Keywords:
CHOLECYSTOKININ; ANIONIC TRYPSIN; CATIONIC TRYPSIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A. Borgstrom et al., "STIMULATION WITH CHOLECYSTOKININ LEADS TO INCREASED RATIO BETWEEN MESSENGER-RNA LEVELS FOR ANIONIC AND CATIONIC TRYPSINOGEN IN RAT PANCREAS", Journal of gastroenterology, 32(6), 1997, pp. 797-800

Abstract

An increased ratio between serum levels of immunoreactive anionic andcationic trypsin is a common finding in many forms of pancreatic disease. Experimental studies have shown that increased stimulation with cholecystokinin (CCK) leads to an increase in the ratio between the pancreatic content of anionic and cationic trypsin. To study whether thiseffect ij caused by increased pancreatic synthesis of anionic trypsinin relation to cationic trypsin we studied the levels of mRNA for anionic and cationic trypsinogen in pancreatic extracts from rats exposedto increased CCK levels through chronic subcutaneous administration of CCK. Northern blot and slot blot hybridization techniques were used. The ratio between mRNAs for anionic and cationic trypsin was significantly higher in CCK-treated rats: median level, 2.04 (range, 1.33-4.08) versus a median level of 1.15 (range, 0.97-2.17) in the control group; P < 0.01. These findings support the view that chronic CCK stimulation leads to the increased synthesis of anionic trypsinogen compared to cationic trypsinogen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:58:20