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Titolo:
DUAL EFFECT OF ATP AND UTP ON RAT ATRIA - WHICH TYPES OF RECEPTORS ARE INVOLVED
Autore:
FROLDI G; PANDOLFO L; CHINELLATO A; RAGAZZI E; CAPARROTTA L; FASSINA G;
Indirizzi:
UNIV PADUA,DEPT PHARMACOL,LARGO E MENEGHETTI 2 I-35131 PADUA ITALY
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 4, volume: 349, anno: 1994,
pagine: 381 - 386
SICI:
0028-1298(1994)349:4<381:DEOAAU>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE VAS-DEFERENS; GUINEA-PIG; ADENOSINE RECEPTORS; ALPHA,BETA-METHYLENE ATP; ADENINE-NUCLEOTIDES; CYCLIC-AMP; SURAMIN; P2-PURINOCEPTOR; ANTAGONIST; RESPONSES;
Keywords:
ATP; UTP; ADENOSINE; SURAMIN; P-1-PURINOCEPTORS; P-2-PURINOCEPTORS; POSITIVE INOTROPISM; RAT LEFT ATRIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
G. Froldi et al., "DUAL EFFECT OF ATP AND UTP ON RAT ATRIA - WHICH TYPES OF RECEPTORS ARE INVOLVED", Naunyn-Schmiedeberg's archives of pharmacology, 349(4), 1994, pp. 381-386

Abstract

The effects of adenine compounds and UTP were examined in electrically driven rat left atria. ATP, ADP, AMP, adenosine and UTP caused a dual inotropic effect: first a rapid decrease in contractility, and second an increase in contractile tension. alpha,beta-Methylene ATP caused an increase in contractile tension only, whereas 2-methylthio-ATP onlyinduced a negative inotropic effect. 1,3-Dipropyl-8-cyclopentylxanthine inhibited the negative effects of ATP and adenosine, whereas 3,7-dimethyl-1-propargylxanthine did not influence the effects of ATP. Suramin but not reactive blue 2 antagonized the positive inotropism inducedby ATP and alpha,beta-methylene ATP. Suramin also abolished the positive inotropic effect induced by UTP. These results demonstrate that ATP may induce negative inotropism directly by an action on A(1)-adenosine receptors and positive inotropism by an action on P-2x-purinoceptors. UTP induces a positive inotropic effect mediated by suramin-sensitive receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:48:23