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Titolo:
IS6110 FINGERPRINTING OF DRUG-RESISTANT MYCOBACTERIUM-TUBERCULOSIS STRAINS ISOLATED IN GERMANY DURING 1995
Autore:
NIEMANN S; RUSCHGERDES S; RICHTER E;
Indirizzi:
NATL REFERENCE CTR MYCOBACTERIA,FORSCHUNGZENTRUM BORSTEL,PARKALLEE 18D-23845 BORSTEL GERMANY NATL REFERENCE CTR MYCOBACTERIA,FORSCHUNGZENTRUM BORSTEL D-23845 BORSTEL GERMANY
Titolo Testata:
Journal of clinical microbiology
fascicolo: 12, volume: 35, anno: 1997,
pagine: 3015 - 3020
SICI:
0095-1137(1997)35:12<3015:IFODMS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGMENT-LENGTH-POLYMORPHISM; NEW-YORK-CITY; INSERTION-SEQUENCE; EXOGENOUS REINFECTION; EPIDEMIOLOGY; TRANSMISSION; INFECTION; HOMELESS; OUTBREAK; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Niemann et al., "IS6110 FINGERPRINTING OF DRUG-RESISTANT MYCOBACTERIUM-TUBERCULOSIS STRAINS ISOLATED IN GERMANY DURING 1995", Journal of clinical microbiology, 35(12), 1997, pp. 3015-3020

Abstract

The epidemiological relatedness of drug-resistant Mycobacterium tuberculosis strains isolated in Germany in 1995 was evaluated by the standardized IS6110 fingerprinting method. Altogether, 196 M. tuberculosis isolates from 167 patients were analyzed. A large degree of IS6110 polymorphism was found, ranging from 1 to 20 copies. Multiple isolates from one patient generally remained stable over a period of up to 1 year. However, one strain showed an additional fragment 7 months after thefirst isolate was obtained. Isolates from 55 patients (33%) showed identical fingerprint patterns or fingerprint patterns that differed only in one band, and thus they were clustered in 22 fingerprint groups. Specific transmission links could be established between members of four groups, e.g., transmission by family contacts. In one case, transmission of a multidrug-resistant strain to a patient initially infected with a drug-susceptible strain could be shown. Besides these fingerprint groups, 30 of the 167 isolates (approximately 18%) could be groupedin two fingerprint clusters,vith a similarity of at least 78%. Approximately 60% of the patients of these two clusters were known to be immigrants from the former Soviet Union, and one patient is still living in Belarus. In conclusion, our results indicate that (i) transmission of drug-resistant strains contributes substantially to the emergence of drug-resistant tuberculosis in Germany and (ii) drug-resistant M. tuberculosis strains were presumably carried over from the former SovietUnion to Germany by immigrants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:44:36