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Titolo:
INTESTINAL AND EXTRAINTESTINAL TUMOR MULTIPLICITIES IN THE APC1638N MOUSE MODEL AFTER EXPOSURE TO X-RAYS
Autore:
VANOORDT CWV; SMITS R; WILLIAMSON SLH; LUZ A; KHAN PM; FODDE R; VANDEREB AJ; BREUER ML;
Indirizzi:
LEIDEN UNIV,DEPT MOL CARCINOGENESIS,POB 9305 NL-2300 RA LEIDEN NETHERLANDS LEIDEN UNIV,DEPT MOL CARCINOGENESIS NL-2300 RA LEIDEN NETHERLANDS LEIDEN UNIV,DEPT HUMAN GENET NL-2300 RA LEIDEN NETHERLANDS UNIV NEWCASTLE UPON TYNE,ROYAL INFIRM,DEPT PATHOL NEWCASTLE TYNE NE1 4LP TYNE & WEAR ENGLAND GSF MUNICH,DEPT PATHOL D-85758 NEUHERBERG GERMANY
Titolo Testata:
Carcinogenesis
fascicolo: 11, volume: 18, anno: 1997,
pagine: 2197 - 2203
SICI:
0143-3334(1997)18:11<2197:IAETMI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
APC GENE-PRODUCT; COLORECTAL TUMORIGENESIS; SUPPRESSOR PROTEIN; CELL-PROLIFERATION; IONIZING-RADIATION; BETA-CATENIN; IN-VITRO; MUTATION; MICE; HETEROZYGOSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
C.W.V. Vanoordt et al., "INTESTINAL AND EXTRAINTESTINAL TUMOR MULTIPLICITIES IN THE APC1638N MOUSE MODEL AFTER EXPOSURE TO X-RAYS", Carcinogenesis, 18(11), 1997, pp. 2197-2203

Abstract

Seven-week-old Apc1638N mice were exposed to a single dose of 5 Gy total-body X-irradiation resulting in a 8-fold increase in the number ofintestinal tumors and a reduction of the lifespan to an average of 6 months. The distribution of tumors along the intestinal tract as well as the adenoma/carcinoma carcinoma ratio, were similar between non-irradiated and irradiated animals, Semi-quantitative PCR analysis of intestinal-tumor DNA revealed that 10 out of 14 tumors had lost the wild-type Ape allele, However, in contrast to spontaneous Apc1638N intestinal tumors in which the LOH event at the Ape locus involves the entire chromosome 18 (1), in 6 out of 10 tumors derived from X-irradiated animals the Ape loss is associated with only a partial intrachromosomal deletion, The remaining tumors have lost all chromosome 18 markers tested, In addition to the intestinal tumors, female Apc1638N mice are susceptible to the development of mammary tumors, Upon X-irradiation, Apc1638N mice show a striking 15-fold increase in mammary tumors, Moreover, Apc1638N mice spontaneously develop other extra-intestinal neoplasia, such as desmoid-like lesions similar to those associated with familial adenomatous polyposis (FAP), the human syndrome caused by germline mutations in the APC gene, Spontaneous desmoid growth is sex-dependent, as male Apc1638N mice develop 3-fold more desmoids than female mice,Interestingly, X-irradiation seemed to increase the number of desmoids per animal nearly twofold only in female Apc1638N mice, Five out of 9 desmoids found in Apc1638N mice exposed to X-ray displayed loss of the wild-type Ape allele.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:25:56