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Titolo:
RHEOLOGIC EFFECTS OF PLASMA SUBSTITUTES USED FOR PREOPERATIVE HEMODILUTION
Autore:
AUDIBERT G; DONNER M; LEFEVRE JC; STOLTZ JF; LAXENAIRE MC;
Indirizzi:
CHU NANCY,HOP CENT,DEPT ANESTHESIE REANIMAT,29 AVE LATTRE DE TASSIGNY,CASE OFFICIELLE 34 F-54037 NANCY FRANCE CHU NANCY,HOP BRABOIS,INSERM,U284 F-54037 NANCY FRANCE
Titolo Testata:
Anesthesia and analgesia
fascicolo: 4, volume: 78, anno: 1994,
pagine: 740 - 745
SICI:
0003-2999(1994)78:4<740:REOPSU>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-VISCOSITY; NORMOVOLEMIC HEMODILUTION; DISEASE; INVIVO; SURGERY; ALBUMIN; INVITRO; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G. Audibert et al., "RHEOLOGIC EFFECTS OF PLASMA SUBSTITUTES USED FOR PREOPERATIVE HEMODILUTION", Anesthesia and analgesia, 78(4), 1994, pp. 740-745

Abstract

This study was designed to compare the influence of various plasma substitutes, administered for preoperative hemodilution, on blood rheology. We studied 40 patients, ASA grade I, who underwent elective facialreconstructive surgery and received 4% albumin (n = 10), 3.5% dextran40 (n = 10), gelatin (n = 10), or hydroxyethyl starch (HES) (n = 10). Ten patients, undergoing the same surgical procedure without hemodilution, were chosen as controls. After hemodilution, hematocrit was decreased approximately 30%. Fibrinogen decreased in all tested groups except in the gelatin group. Plasma viscosity decreased with albumin (1.13 +/- 0.05 to 1.06 +/- 0.03 mPa.s; P < 0.01) and increased with HES (1.15 +/- 0.04 to 1.22 +/- 0.05 mPa.s; P < 0.01). At a high shear rate, the blood viscosity decreased in all groups. In contrast, at a low shear rate and at 40% corrected hematocrit, the blood viscosity decreasedin the albumin (15.9 +/- 1.9 to 13.1 +/- 2.1 mPa.s; P < 0.01) and thedextran 40 (16.9 +/- 2.9 to 12.8 +/- 2.5 mPa.s; P < 0.01) groups and was unchanged in the gelatin and the HES groups. Erythrocyte aggregation (measured with primary aggregation time) was markedly decreased in the albumin (3.27 +/- 1.74 to 7.03 +/- 2.95 s; P < 0.01) and in the dextran 40 (2.72 +/- 0.58 to 6.24 +/-2.55 s; P < 0.001) groups, unchanged with HES, and increased with gelatin (2.41 +/- 0.90 to 1.55 +/- 0.33s). These findings suggest that albumin and dextran 40 may be the plasma substitutes of choice for preoperative hemodilution when this technique aims to improve rheologic conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:16:38