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Titolo:
DECREASED ACTIVITY OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN MESENTERIC-ARTERIES OF DAHL SALT-SENSITIVE RATS
Autore:
TAKEDA Y; MIYAMORI I; YONEDA T; HATAKEYAMA H; IKI K; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA-MACHI KANAZAWA 920 JAPAN
Titolo Testata:
Life sciences
fascicolo: 18, volume: 54, anno: 1994,
pagine: 1343 - 1349
SICI:
0024-3205(1994)54:18<1343:DAO1DI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HYPERTENSION; ACID;
Keywords:
11-BETA-HYDROXYSTEROID DEHYDROGENASE; DAHL SALE-SENSITIVE RAT; NOREPINEPHRINE; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "DECREASED ACTIVITY OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN MESENTERIC-ARTERIES OF DAHL SALT-SENSITIVE RATS", Life sciences, 54(18), 1994, pp. 1343-1349

Abstract

11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) activity in mesenteric arteries of 4-week- and 8-week-old Dahl rats was determined to evaluate the relationship between glucocorticoids and norepinephrine in hypertension. 11 beta-HSD activity (expressed as the percentage conversion of H-3-corticosterone (B) to H-3-11-dehydrocorticosterone (A)) significantly decreased in 8-week-old Dahl salt-sensitive (DS) rats (11.4 +/- 1.4%) compared with Dahl salt-resistant (DR) rats (15.3 +/- 0.3%) (p<0.05) when each group was fed a high-sodium chow (7%) for 4 weeks. There were no significant differences in 11 beta-HSD activity in the4-week-old DS and DR rats. The enhanced response of mesenteric arteries to norepinephrine was observed only in 8-week-old DS rats. Our results suggest that a decreased 11 beta-HSD activity in the vascular walls contributes to the increased response of norepinephine by local increment of glucocorticoids in DS hypertensive rats.

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Documento generato il 30/11/20 alle ore 16:17:57