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Titolo:
ROLE OF THE THE PERITONEAL FIBROBLASTS FO R INFLAMMATORY REACTIONS OFTHE PERITONEUM
Autore:
JORRES A; LUDAT K; SANDER K; DUNKEL K; LORENZ F; BENDER TO; FINN A; FREI U; GAHL GM;
Indirizzi:
AUGUSTENBURGER PLATZ 1 D-13353 BERLIN GERMANY HUMBOLDT UNIV BERLIN,FAK MED,VIRCHOW KLINIKUM,ABT INNERE MED SCHWERPUNKT NEPHROL & INTERNIST IN D-1040 BERLIN GERMANY
Titolo Testata:
Nieren- und Hochdruckkrankheiten
, volume: 26, anno: 1997, supplemento:, 1
pagine: 34 - 38
SICI:
0300-5224(1997)26:<34:ROTTPF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
GER
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN DERMAL FIBROBLASTS; FACTOR-ALPHA; MESSENGER-RNA; RECOMBINANT INTERLEUKIN-1; SYNERGISTIC STIMULATION; INTERFERON-GAMMA; GENE-EXPRESSION; DIALYSIS; PROSTAGLANDIN-E2;
Keywords:
PERITONEAL DIALYSIS; PERITONEAL HOST DEFENSE; FIBROBLASTS; CELL CULTURE; CYTOKINES; EICOSANOIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A. Jorres et al., "ROLE OF THE THE PERITONEAL FIBROBLASTS FO R INFLAMMATORY REACTIONS OFTHE PERITONEUM", Nieren- und Hochdruckkrankheiten, 26, 1997, pp. 34-38

Abstract

In recent years evidence is accumulating that the peritoneal membraneis intrinsically involved in the control of peritoneal inflammation. In particular, the role of the peritoneal mesothelium, but not of the interstitial fibroblasts, has been investigated in recent studies. We have therefore established and characterized a cell culture model using human peritoneal fibroblasts (HPFB). These cells were isolated from human omentum and their synthesis of cytokines and prostaglandins was evaluated. The stimulation of peritoneal fibroblasts with macrophage-derived cytokines or culture supernatants of peritoneal macrophages resulted in a dose-and time-dependent induction of mRNA for IL-6 and IL-8as well as in increased secretion of these cytokines into the HPFB supernatants. Similarly activated HPFB showed increased expression of cyclooxygenase-2 (cox-2) mRNA and prostaglandin synthesis. Tnt se results indicate that in addition to the peritoneal mesothelium, the peritoneal fibroblasts may play an important role in the initiation and control of inflammatory processes of the peritoneum during peritoneal dialysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:16:03