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Titolo:
TISSUE-SPECIFIC REGULATION OF G-PROTEIN-COUPLED INWARDLY RECTIFYING K+ CHANNEL EXPRESSION BY MUSCARINIC RECEPTOR ACTIVATION IN OVO
Autore:
THOMAS SL; CHMELAR RS; LU CW; HALVORSEN SW; NATHANSON NM;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT PHARMACOL,BOX 357750 SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT PHARMACOL SEATTLE WA 98195 SUNY BUFFALO,DEPT BIOCHEM PHARMACOL BUFFALO NY 14260
Titolo Testata:
The Journal of biological chemistry
fascicolo: 47, volume: 272, anno: 1997,
pagine: 29958 - 29962
SICI:
0021-9258(1997)272:47<29958:TROGIR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC CHICK HEART; GTP-BINDING PROTEINS; ACETYLCHOLINE-RECEPTOR; POTASSIUM CHANNELS; CHOLINERGIC RECEPTORS; OPIOID RECEPTORS; XENOPUS OOCYTES; ATRIAL CELLS; RAT-BRAIN; AGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Thomas et al., "TISSUE-SPECIFIC REGULATION OF G-PROTEIN-COUPLED INWARDLY RECTIFYING K+ CHANNEL EXPRESSION BY MUSCARINIC RECEPTOR ACTIVATION IN OVO", The Journal of biological chemistry, 272(47), 1997, pp. 29958-29962

Abstract

We investigated the effects of muscarinic acetylcholine receptor stimulation on the expression levels of the G-protein-coupled inwardly rectifying K+ channel (GIRK) subunits using solution hybridization and immunoblot analyses, We report here that treatment of chick embryos in ovo with muscarinic agonist causes decreases in mRNA levels encoding GIRK1 and GIRK4 in atria but does not alter GIRK1 expression in ventricles, In addition, GIRKI protein levels also demonstrate a decrease in atria upon muscarinic acetylcholine receptor stimulation, Numerous receptors couple to the activation of the GIRK family of inwardly rectifying K+ channels; thus, these decreases represent a novel mechanism for regulating physiological responses to chronic agonist exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:17:57