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Titolo:
EVAPORATION-INDUCED CHANGES IN AIRWAY SURFACE LIQUID ON AN ISOLATED GUINEA-PIG TRACHEA
Autore:
SHEPHARD KL; RAHMOUNE H;
Indirizzi:
UNIV BUCKINGHAM,CLORE LAB LIFE SCI BUCKINGHAM MK18 1EG ENGLAND
Titolo Testata:
Journal of applied physiology
fascicolo: 3, volume: 76, anno: 1994,
pagine: 1156 - 1165
SICI:
8750-7587(1994)76:3<1156:ECIASL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGIONAL DIFFERENCES; MUCUS SECRETION; ION-TRANSPORT; EPITHELIUM; INVITRO; FLUID; TEMPERATURE; HUMIDITY; HEAT; FLOW;
Keywords:
NET WATER TRANSPORT; NET SODIUM TRANSPORT; ION-SELECTIVE MICROELECTRODES; MUCUS; REGULATORY PROCESSES IN THE AIRWAY; TRANSEPITHELIAL POTENTIAL DIFFERENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
K.L. Shephard e H. Rahmoune, "EVAPORATION-INDUCED CHANGES IN AIRWAY SURFACE LIQUID ON AN ISOLATED GUINEA-PIG TRACHEA", Journal of applied physiology, 76(3), 1994, pp. 1156-1165

Abstract

Evaporation-induced changes in airway surface liquid on an isolated guinea pig trachea. J. Appl. Physiol. 76(3): 1156-1165, 1994. - An isolated preparation of the guinea pig trachea was developed. The trachea was exposed serosally to Krebs-Henseleit solution and mucosally to tidal airflow, designed to mimic conditions in vivo. The preparation establishes stable layers of airway surface liquid (ASL). Typical depth, transepithelial potential differences, and sodium activity are 200 mu m, -3 mV, and 125 mM, respectively (approximate sodium concn 170 mM). When exposed to air with a vapor pressure deficit (VPD), evaporation ofwater occurs from ASL, ASL depth decreases, and the concentration of sodium ions in ASL increases. The water content of air passing over the trachea also increases. This measurement is compared with measurements of the change in volume of ASL, based on depth changes, to yield estimates of net water transport (NWT). Measurements of changes in the sodium content of ASL allow for the calculation of net sodium transportby the trachea. Evaporation rate, changes in the volume of ASL, NWT, and net sodium transport are all influenced by VPD. The results suggest that evaporation from ASL increases its sodium concentration (and osmotic pressure) and increases osmotically driven NWT to replace water lost. Evaporation-induced increases in the sodium concentration appearto be limited by enhanced sodium uptake at high VPD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:40:38