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Titolo:
REPEATED DOSES OF THE PERFLUOROCARBON FC-100 IMPROVE LUNG-FUNCTION OFPRETERM LAMBS
Autore:
MOYA FR; LLANOS AJ; RIOS AM; RIQUELME RA; MORAGA FA; RUBIO LA; SALVO HD; JACOBS HC;
Indirizzi:
UNIV TEXAS,SW MED CTR,SCH MED,DEPT PEDIAT,DIV NEONATOL,6431 FANNIN,SUITE 3242 HOUSTON TX 77030 UNIV CHILE,FAC MED,DEPT EXPT MED SANTIAGO 7 CHILE HOSP SALVADOR,UNIDAD NEONATOL SANTIAGO CHILE UNIV CHILE,FAC CIENCIAS QUIM & FARMACEUT,DEPT BIOQUIM & BIOL MOL SANTIAGO CHILE YALE UNIV,SCH MED,DEPT PEDIAT NEW HAVEN CT 06510
Titolo Testata:
Pediatric research
fascicolo: 6, volume: 42, anno: 1997,
pagine: 893 - 898
SICI:
0031-3998(1997)42:6<893:RDOTPF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; PARTIAL LIQUID VENTILATION; SURFACTANT REPLACEMENT THERAPY; GAS-EXCHANGE; EXOGENOUS SURFACTANT; SYNTHETIC SURFACTANT; PREMATURE LAMBS; PULMONARY MECHANICS; NATURAL SURFACTANT; CONTROLLED TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
F.R. Moya et al., "REPEATED DOSES OF THE PERFLUOROCARBON FC-100 IMPROVE LUNG-FUNCTION OFPRETERM LAMBS", Pediatric research, 42(6), 1997, pp. 893-898

Abstract

Intratracheal administration of a single dose of the perfluorocarbon FC-100 improves lung function in surfactant-deficient animals. In thisstudy we compared the response to repeated doses of FC-100 (3 mL/kg 3% solution, n = 5) with that observed after administration of Exosurf (5 mL/kg, n = 5) to mechanically ventilated preterm lambs of 125 d of gestation. The initial dose of FC-100 rapidly increased arterial Po-2,decreased arterial Pco(2), and improved arterial pH. Also dynamic lung compliance markedly improved with this agent. Administration of an additional dose of FC-100 resulted in relatively similar changes, albeit of lesser magnitude than those observed with the initial dose. In contrast, Exosurf did not improve these variables even after three doses. All lambs treated with FC-100 survived the 6-h study period, whereasone of the five Exosurf-treated lambs survived (p < 0.05). Mean arterial blood pressure and heart rate decreased in those lambs that received FC-100, but not in surviving lambs that received Exosurf. Our data demonstrate that repeated intratracheal administration of the perfluorocarbon FC-100 improves lung function and survival of surfactant deficient lambs better than the synthetic surfactant Exosurf. We speculate that tensio-active agents with properties different from surfactant, such as FC-100, might improve lung function in preterm neonates with diseases due to surfactant deficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:36:06