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Titolo:
DOUBLE DISSOCIATION BETWEEN THE INVOLVEMENT OF THE BED NUCLEUS OF THESTRIA TERMINALIS AND THE CENTRAL NUCLEUS OF THE AMYGDALA IN STARTLE INCREASES PRODUCED BY CONDITIONED VERSUS UNCONDITIONED FEAR
Autore:
WALKER DL; DAVIS M;
Indirizzi:
CONNECTICUT MENTAL HLTH CTR,34 PK ST,3RD FLOOR NEW HAVEN CT 06508 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 06508
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 17, anno: 1997,
pagine: 9375 - 9383
SICI:
0270-6474(1997)17:23<9375:DDBTIO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; POTENTIATED STARTLE; BASOLATERAL AMYGDALA; INTRINSIC CONNECTIONS; TEMPORAL GRADIENT; ACOUSTIC STARTLE; LESIONS; RAT; PROJECTIONS; COMPLEX;
Keywords:
AMYGDALA; BED NUCLEUS OF THE STRIA TERMINALIS; GLUTAMATE; AMPA; FEAR; ANXIETY; MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Walker e M. Davis, "DOUBLE DISSOCIATION BETWEEN THE INVOLVEMENT OF THE BED NUCLEUS OF THESTRIA TERMINALIS AND THE CENTRAL NUCLEUS OF THE AMYGDALA IN STARTLE INCREASES PRODUCED BY CONDITIONED VERSUS UNCONDITIONED FEAR", The Journal of neuroscience, 17(23), 1997, pp. 9375-9383

Abstract

The amplitude of the acoustic startle response is reliably enhanced when elicited in the presence of bright light (light-enhanced startle) or in the presence of cues previously paired with shock (fear-potentiated startle). Light-enhanced startle appears to reflect an unconditioned response to an anxiogenic stimulus, whereas fear-potentiated startle reflects a conditioned response to a fear-eliciting stimulus. We examine the involvement of the basolateral nucleus of the amygdala, the central nucleus of the amygdala, and the bed nucleus of the stria terminalis in both phenomena. Immediately before light-enhanced or fear-potentiated startle testing, rats received intracranial infusions of the AMPA receptor antagonist dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (3 mu g) or PBS. Infusions into the central nucleus of the amygdala blocked fear-potentiated but not light-enhanced startle, and infusions into the bed nucleus of the stria terminalis blocked light-enhanced but not fear-potentiated startle. Infusions into the basolateral amygdala disrupted both phenomena. These findings indicate that the neuroanatomical substrates of fear-potentiated and light-enhanced startle,and perhaps more generally of conditioned and unconditioned fear, maybe anatomically dissociated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 22:13:11