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Titolo:
INTERACTION OF GABA AND EXCITATORY AMINO-ACIDS IN THE BASOLATERAL AMYGDALA - ROLE IN CARDIOVASCULAR REGULATION
Autore:
SOLTIS RP; COOK JC; GREGG AE; SANDERS BJ;
Indirizzi:
DRAKE UNIV,COLL PHARM & HLTH SCI,DEPT PHARMACEUT SCI,2507 UNIV AVE DES MOINES IA 50311 DRAKE UNIV,COLL PHARM & HLTH SCI,DEPT PSYCHOL DES MOINES IA 50311
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 17, anno: 1997,
pagine: 9367 - 9374
SICI:
0270-6474(1997)17:23<9367:IOGAEA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; RAT AMYGDALA; BRAIN-STEM; HEART-RATE; RECEPTORS; PROJECTIONS; ANTAGONIST; INFUSION; BLOCKADE; TRANSMISSION;
Keywords:
BASOLATERAL AMYGDALA; EXCITATORY AMINO ACIDS; NMDA; AMPA; BICUCULLINE; KYNURENIC ACID; L-TRANS-PDC; HEART RATE; ARTERIAL PRESSURE; CARDIOVASCULAR CONTROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Soltis et al., "INTERACTION OF GABA AND EXCITATORY AMINO-ACIDS IN THE BASOLATERAL AMYGDALA - ROLE IN CARDIOVASCULAR REGULATION", The Journal of neuroscience, 17(23), 1997, pp. 9367-9374

Abstract

Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal. The objective ofthe present study was to examine the interaction of GABA and excitatory amino acid (EAA) receptors in the basolateral amygdala (BLA) in regulating cardiovascular function. Microinjection of the GABA(A) receptor antagonist bicuculline methiodide (BMI) or the EAA receptor agonistsNMDA or AMPA into the same region of the BLA of conscious rats produced dose-related increases in heart rate and arterial pressure. Injection of the nonselective EAA receptor antagonist kynurenic acid into theBLA prevented or reversed the cardiovascular changes caused by local injection of BMI or the noncompetitive GABA antagonist picrotoxin. Conversely, local pretreatment with the glutamate reuptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid enhanced the effects of intra-amygdalar injection of BMI. The cardiovascular effects of BMI were also attenuated by injection of either the NMDA antagonist 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) or the AMPA receptor antagonist -nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide (NBQX). When these two EAA receptor antagonists were combined, their ability to suppress BMI-induced tachycardic and presser responses was additive. Thesefindings indicate that the cardiovascular effects caused by blockade of GABAergic inhibition in the BLA of the rat are dependent on activation of local NMDA and AMPA receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:41:18