Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SELECTIVE SYNAPTIC DISTRIBUTION OF KAINATE RECEPTOR SUBUNITS IN THE 2PLEXIFORM LAYERS OF THE RAT RETINA
Autore:
BRANDSTATTER JH; KOULEN P; WASSLE H;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,ABT NEUROANAT,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 17, anno: 1997,
pagine: 9298 - 9307
SICI:
0270-6474(1997)17:23<9298:SSDOKR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE-RECEPTOR; AMINO-ACID RECEPTORS; ROD BIPOLAR CELLS; MAMMALIAN RETINA; IMMUNOCYTOCHEMICAL LOCALIZATION; DEVELOPMENTAL EXPRESSION; GOLDFISH RETINA; MESSENGER-RNAS; KAINIC ACID; CAT RETINA;
Keywords:
GLUR6/7; KA2; DELTA-1/2; KAINATE RECEPTOR SUBUNITS; HORIZONTAL CELLS; OFF BIPOLAR CELLS; ON BIPOLAR CELLS; AMACRINE CELLS; GANGLION CELLS; OUTER PLEXIFORM LAYER; INNER PLEXIFORM LAYER; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Brandstatter et al., "SELECTIVE SYNAPTIC DISTRIBUTION OF KAINATE RECEPTOR SUBUNITS IN THE 2PLEXIFORM LAYERS OF THE RAT RETINA", The Journal of neuroscience, 17(23), 1997, pp. 9298-9307

Abstract

The synaptic localization of the kainate receptor subunits GluR6/7 and KA2 and of the ionotropic glutamate receptor subunits delta 1/2 was studied in the rat retina using receptor-specific antisera. GluR6/7 and KA2 were present in both synaptic layers of the retina: the inner plexiform layer (IPL) and the outer plexiform layer (OPL). The localization of delta 1/2 was restricted to the IPL. Detailed ultrastructural examination showed that in the OPL GluR6/7 was localized in horizontal cell processes postsynaptic to both rod spherules and cone pedicles. It was always only one of the two invaginating horizontal cell processes at the photoreceptor synapses labeled for GluR6/7. KA2 in the OPL was found only postsynaptic to cone pedicles and never postsynaptic to rod spherules. The KA2-labeled processes made flat contacts with the cone pedicles, suggesting they are the dendrites of OFF bipolar cells. In the IPL the different receptor subunits were localized postsynaptically to ribbon synapses of both rod and cone bipolar cells. As a rule, only one of the two postsynaptic elements at the bipolar cell dyad wasstained for each of the receptor subunits examined. The selective andheterogeneous distribution of these receptors at the ribbon synapses of the OPL and IPL suggests a high degree of differential processing of the glutamatergic signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:24:33