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Titolo:
DISSOCIABLE FORMS OF INHIBITORY CONTROL WITHIN PREFRONTAL CORTEX WITHAN ANALOG OF THE WISCONSIN CARD SORT TEST - RESTRICTION TO NOVEL SITUATIONS AND INDEPENDENCE FROM ONLINE PROCESSING
Autore:
DIAS R; ROBBINS TW; ROBERTS AC;
Indirizzi:
UNIV CAMBRIDGE,DEPT ANAT,DOWNING ST CAMBRIDGE CB2 3DY ENGLAND UNIV CAMBRIDGE,DEPT ANAT CAMBRIDGE CB2 3DY ENGLAND UNIV CAMBRIDGE,DEPT EXPT PSYCHOL CAMBRIDGE CB2 3EB ENGLAND
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 17, anno: 1997,
pagine: 9285 - 9297
SICI:
0270-6474(1997)17:23<9285:DFOICW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE DAMAGE; RHESUS-MONKEYS; EXCITOTOXIC LESIONS; HUMAN INFANTS; MEMORY; DEFICITS; OBJECT;
Keywords:
ATTENTIONAL SET-SHIFTING; REVERSAL LEARNING; PREFRONTAL CORTEX; RESPONSE INHIBITION; WISCONSIN CARD SORT TEST; WORKING MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R. Dias et al., "DISSOCIABLE FORMS OF INHIBITORY CONTROL WITHIN PREFRONTAL CORTEX WITHAN ANALOG OF THE WISCONSIN CARD SORT TEST - RESTRICTION TO NOVEL SITUATIONS AND INDEPENDENCE FROM ONLINE PROCESSING", The Journal of neuroscience, 17(23), 1997, pp. 9285-9297

Abstract

Attentional set-shifting and discrimination reversal are sensitive toprefrontal damage in the marmoset in a manner qualitatively similar to that seen in man and Old World monkeys, respectively (Dias et al., 1996b), Preliminary findings have demonstrated that although lateral but not orbital prefrontal cortex is the critical locus in shifting an attentional set between perceptual dimensions, orbital but not lateral prefrontal cortex is the critical locus in reversing a stimulus-rewardassociation within a particular perceptual dimension (Dias et al., 1996a). The present study presents this analysis in full and extends theresults in three main ways by demonstrating that (1) mechanisms of inhibitory control and ''on-line'' processing are independent within theprefrontal cortex, (2) impairments in inhibitory control induced by prefrontal damage are restricted to novel situations, and (3) those prefrontal areas involved in the suppression of previously established response sets are not involved in the acquisition of such response sets. These findings suggest that inhibitory control is a general process that operates across functionally distinct regions within the prefrontal cortex. Although damage to lateral prefrontal cortex causes a loss of inhibitory control in attentional selection, damage to orbitofrontalcortex causes a loss of inhibitory control in affective processing. These findings provide an explanation for the apparent discrepancy between human and nonhuman primate studies in which disinhibition as measured on the Wisconsin Card Sort Test is associated with dorsolateral prefrontal damage, whereas disinhibition as measured on discrimination reversal is associated with orbitofrontal damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:40:00