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Titolo:
EFFECT OF CENTRAL 5-HYDROXYTRYPTAMINE DEPLETION ON PERFORMANCE IN THETIME LEFT PROCEDURE - FURTHER EVIDENCE FOR A ROLE OF THE 5-HYDROXYTRYPTAMINERGIC PATHWAYS IN BEHAVIORAL SWITCHING
Autore:
ALRUWAITEA ASA; ALZAHRANI SSA; HO MY; BRADSHAW CM; SZABADI E;
Indirizzi:
UNIV NOTTINGHAM,QUEENS MED CTR,DEPT PSYCHIAT NOTTINGHAM NG7 2UH ENGLAND UNIV NOTTINGHAM,QUEENS MED CTR,DEPT PSYCHIAT NOTTINGHAM NG7 2UH ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 134, anno: 1997,
pagine: 179 - 186
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPERANT PSYCHOPHYSICAL PROCEDURE; SCALAR EXPECTANCY-THEORY; INTERVAL BISECTION TASK; TEMPORAL DISCRIMINATION; TIMING BEHAVIOR; CHOICE; LESIONS; DESTRUCTION; ACQUISITION; DURATION;
Keywords:
5-HYDROXYTRYPTAMINE; 5,7-DIHYDROXYTRYPTAMINE; OPERANT BEHAVIOR; TIMING; BEHAVIORAL SWITCHING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A.S.A. Alruwaitea et al., "EFFECT OF CENTRAL 5-HYDROXYTRYPTAMINE DEPLETION ON PERFORMANCE IN THETIME LEFT PROCEDURE - FURTHER EVIDENCE FOR A ROLE OF THE 5-HYDROXYTRYPTAMINERGIC PATHWAYS IN BEHAVIORAL SWITCHING", Psychopharmacology, 134(2), 1997, pp. 179-186

Abstract

This experiment examined the effect of destruction of the ascending 5-hydroxytryptaminergic (5HTergic) pathways on performance in a free-operant timing schedule: the ''time-left'' procedure. Rats received either injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei or sham lesions. They were trained in a discrete trials schedule in which reinforcers were provided for responding on either of two levers, A and B. At a random time point, t s after the start of each trial, a response on A resulted in the delivery of one food pellet after d(A) s, whereas a response on B resulted in the delivery of two pellets after 60-t s. The value of d(A) was varied between 1 and 8 s indifferent phases of the experiment. Both groups showed decreasing response rates on lever A and increasing response rates on lever B as a function of time within the trial. An index of timing (T-75: the time within the trial at which relative response rate on B attained a value of 75%) was systematically related to the value of d(A), but did not differ significantly between lesioned and control rats. However the lesioned group showed significantly higher rates of switching bi:tween response alternatives than the sham-lesioned group at all values of d(A). The levels of 5HT and 5-hydroxyindoleacetic acid were reduced in thebrains of the lesioned rats, but the levels of noradrenaline and dopamine were not significantly altered. The results provide further evidence that the ascending 5HTergic pathways may contribute to the inhibitory regulation of switching between behavioural states.

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Documento generato il 08/04/20 alle ore 11:01:59