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Titolo:
A TIME-ACTIVITY BASE-LINE TO MEASURE PHARMACOLOGICAL AND NONPHARMACOLOGICAL MANIPULATIONS OF PCP-INDUCED ACTIVITY IN MICE
Autore:
MCALLISTER KH;
Indirizzi:
NOVARTIS PHARMA INC,S-386-226 CH-4002 BASEL SWITZERLAND
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 134, anno: 1997,
pagine: 157 - 163
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE; RATS; NEUROLEPTICS; STIMULATION; AMPHETAMINE; ANTAGONISM; PSYCHOSIS; SYSTEM;
Keywords:
PHENCYCLIDINE (PCP); LOCOMOTION; ATAXIA; TIME; HALOPERIDOL; CHLORDIAZEPOXIDE; PENTOBARBITAL; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Mcallister, "A TIME-ACTIVITY BASE-LINE TO MEASURE PHARMACOLOGICAL AND NONPHARMACOLOGICAL MANIPULATIONS OF PCP-INDUCED ACTIVITY IN MICE", Psychopharmacology, 134(2), 1997, pp. 157-163

Abstract

At critical doses of PCP (10 mg/kg IP in the present studies), locomotor stimulation in mice ij initially suppressed by short-lasting ataxia, albeit at higher levels of activity than controls. This provides a time-activity baseline of PCP-stimulated locomotion potentially sensitive to i) pharmacological antagonism indicated by a change in the time-activity relationship to that seen at lower PCP doses, ii) interaction with the ataxic phase resulting in further decreases in activity similar to that seen at higher PCP doses and iii) reductions in activity without a change in the time-activity relationship. This baseline was explored using three manipulations employed in the clinical managementof PCP toxicity: treatment with a neuroleptic (haloperidol), a benzodiazepine (chlordiazepoxide) and modification in environmental stimulation (changing of lighting conditions). Both haloperidol (0.125-0.5 mg/kg, IP) and chlordiazepoxide (5-20 mg/kg IP) further reduced activityduring the ataxic phase of the PCP time-activity relationship qualitatively similar to the effects of pentobarbital (20-40 mg/kg IP). Changing of lighting conditions from red to white light resulted in significant reductions in levels of activity of PCP-treated animals but no change in the time-activity relationship. No manipulation resulted in true reversal of the PCP induced time-activity relationship. The resultsparallel the clinical findings that neuroleptic and benzodiazepine administration have no specific effects upon PCP-intoxication and that environmental manipulation may modify the degree of PCP stimulation. The time-activity baseline described may prove useful in the evaluation of the effects of pharmacological and nonpharmacological manipulationsof PCP-induced activity in rodents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:12:12