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Titolo:
HLA DR2 - A PREDICTIVE MARKER IN RESPONSE TO CYCLOSPORINE THERAPY IN APLASTIC-ANEMIA
Autore:
IHAN O; BEKSAC M; ARSLAN O; OZCAN M; KOC H; AKAN H; GURMAN G; KONUK N; UYSAL A;
Indirizzi:
ANKARA UNIV,SCH MED,IBN I SINA HOSP,DEPT HEMATOL ONCOL TR-06100 ANKARA TURKEY
Titolo Testata:
International journal of hematology
fascicolo: 3, volume: 66, anno: 1997,
pagine: 291 - 295
SICI:
0925-5710(1997)66:3<291:HD-APM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOZAPINE-INDUCED AGRANULOCYTOSIS; IMMUNOSUPPRESSIVE THERAPY; FREQUENCY; GLOBULIN;
Keywords:
APLASTIC ANEMIA; HLA DR TYPING; IMMUNOSUPPRESSIVE THERAPY; CYCLOSPORINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
O. Ihan et al., "HLA DR2 - A PREDICTIVE MARKER IN RESPONSE TO CYCLOSPORINE THERAPY IN APLASTIC-ANEMIA", International journal of hematology, 66(3), 1997, pp. 291-295

Abstract

The effect of immunosuppressive agents on HLA DR2-aplastic anemia (AA) has recently been investigated by different groups. In the present report, we analyzed 40 Turkish AA patients, who received immunosuppressive therapy (IST) and 12 AA's who were transplanted from HLA matched siblings. HLA DR2 frequency was 0.442 and significantly higher in AA's when compared to an unrelated healthy control group (RR: 2.93, 95% confidence interval 1.48-5.77, P = 0.001. Patients received antithymocyteor antilymphocytic globulin (AT/LG) or AT/LG plus cyclosporine-A. (CsA) or CsA alone. In DR2(+) and DR2(-) patients overall response rates were 73.3 and 30%, respectively (P = 0.03). When patients were analyzed separately, CsA administration either alone or in combination with AT/LG gave favorable results in the DR2(+) group (P = 0.02). In contrast AT/LG presence alone was shown to be inadequate. (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 15/07/20 alle ore 21:35:16