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Titolo:
REGIONAL DECREASES IN [H-3]AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID ([H-3]AMPA) AND 6-[H-3]CYANO-7-NITROQUINOXALINE-2,3-DIONE ([H-3]CNQX) BINDING IN RESPONSE TO CHRONIC LOW-LEVEL LEAD-EXPOSURE - REVERSAL VERSUS POTENTIATION BY CHRONIC DOPAMINE AGONIST TREATMENT
Autore:
MCCOY L; RICHFIELD EK; CORYSLECHTA DA;
Indirizzi:
UNIV ROCHESTER,SCH MED & DENT,DEPT NEUROBIOL & ANAT,BOX 603 ROCHESTERNY 14642 UNIV ROCHESTER,SCH MED & DENT,DEPT NEUROBIOL & ANAT ROCHESTER NY 14642 UNIV ROCHESTER,SCH MED & DENT,DEPT PSYCHIAT ROCHESTER NY 14642 UNIV ROCHESTER,SCH MED & DENT,DEPT NEUROL & PATHOL ROCHESTER NY 14642
Titolo Testata:
Journal of neurochemistry
fascicolo: 6, volume: 69, anno: 1997,
pagine: 2466 - 2476
SICI:
0022-3042(1997)69:6<2466:RDI[>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE; RECEPTOR AFFINITIES; GLUTAMATE RECEPTORS; CHELATION-THERAPY; NUCLEUS-ACCUMBENS; NERVE-TERMINALS; AMPA BINDING; RELEASE; HIPPOCAMPAL; MODULATION;
Keywords:
LPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID; LEAD; GLUTAMATE; DOPAMINE; NUCLEUS ACCUMBENS; DORSAL STRIATUM; FRONTAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
L. Mccoy et al., "REGIONAL DECREASES IN [H-3]AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID ([H-3]AMPA) AND 6-[H-3]CYANO-7-NITROQUINOXALINE-2,3-DIONE ([H-3]CNQX) BINDING IN RESPONSE TO CHRONIC LOW-LEVEL LEAD-EXPOSURE - REVERSAL VERSUS POTENTIATION BY CHRONIC DOPAMINE AGONIST TREATMENT", Journal of neurochemistry, 69(6), 1997, pp. 2466-2476

Abstract

This study evaluated the hypotheses that in vivo lead (Pb) exposure would alter lpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding and, based on known glutamate-dopamine interactions and Pb-induced changes in dopamine (DA) systems, that AMPA binding might be differentially influenced by DA agonist treatment under conditions of Pb exposure. Alterations in high-affinity ([H-3]AMPA) versus total AMPA [6-[H-3] cyano-7-nitroquinoxaline-2,3-dione ([H-3]CNQX)] receptor binding were determined in medial frontal cortex, dorsal striatum, and nucleus accumbens of rats exposed to 0, 50, or 150 ppm of Pb acetate for 2 weeks or 8 months. Additional 8-month groups received chronic intermittent treatment with saline, the D-1 agonist SKF82958, or the general DA agonist apomorphine. Two-week exposures increased AMPA receptor densities, whereas robust decreases occurred after 8 months of Pb; at the latter time point changes were more pronounced for high-affinity than total AMPA receptor binding, with high-affinity effects expressed preferentially in dorsal striatum and nucleus accumbens. DA agonist treatments almost fully reversed Pb-related declines in [H-3]AMPA binding but either had no effect (apomorphine) or even further potentiated (SKF82958) the decreases in [H-3]CNQX binding. One possible basis for the long-term (8-month) decrease in AMPA binding is a postsynaptic glutamatergic stimulation of non-NMDA receptors.

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Documento generato il 21/09/20 alle ore 06:09:19