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Titolo:
EFFECTS OF AMINOGUANIDINE AND L-NAME ON HISTAMINE-INDUCED BLOOD-PRESSURE DROP IN THE RAT
Autore:
NILSSON BO; KOCKUM I; ROSENGREN E;
Indirizzi:
LUND UNIV,DEPT PHYSIOL & NEUROSCI,SOLVEGATAN 19 S-22362 LUND SWEDEN
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 3, volume: 161, anno: 1997,
pagine: 339 - 344
SICI:
0001-6772(1997)161:3<339:EOAALO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIAMINE OXIDASE ACTIVITY; NITRIC-OXIDE; ENDOTHELIUM; INHIBITION; MECHANISMS; RELEASE; CELLS;
Keywords:
AMINOGUANIDINE; BLOOD PRESSURE; DIAMINE OXIDASE; HISTAMINE; L-NAME; NITRIC OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
B.O. Nilsson et al., "EFFECTS OF AMINOGUANIDINE AND L-NAME ON HISTAMINE-INDUCED BLOOD-PRESSURE DROP IN THE RAT", Acta Physiologica Scandinavica, 161(3), 1997, pp. 339-344

Abstract

Mean arterial blood pressure changes in response to i.v. administration of histamine were monitored in the anaesthetized rat in the absenceor presence of the diamine oxidase (DAO) inhibitor aminoguanidine (AMG, 10 mg kg(-1)). AMG prolonged the duration of the transient drop in blood pressure induced by a bolus injection of histamine (0.05 mg kg(-1)) by 34%. In animals pretreated with AMG, no potentiation of the decrease in pressure in response to a 10 min infusion of histamine was observed. However, when infusion was stopped, the time needed for pressure recovery was twice as long in animals treated with AMG as in controls. Blood samples were taken prior to infusion and during the recoveryphase and the quantities of histamine were determined by liquid chromatography. The prolonged recovery phase observed in animals pretreatedwith AMG was associated with five times higher levels of histamine. The curation of histamine-induced hypotension (0.01 mg kg(-1)) was 50% shorter in the presence of the nitric oxide synthase inhibitor I-NAME (10 mg kg(-1)). We suggest that DAO, through elimination of histamine from the bloodstream, is important for the recovery from histamine-induced hypotension, and that the duration of histamine-induced pressure drop is influenced by formation of nitric oxide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:56:18