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Titolo:
ALTERNATIVE TRANSLATION INITIATION CODON FOR THE HUMAN MELANOCORTIN MC(3) RECEPTOR DOES NOT AFFECT THE LIGAND-BINDING
Autore:
SCHIOTH HB; MUCENIECE R; WIKBERG JES; SZARDENINGS M;
Indirizzi:
UPPSALA UNIV,DEPT PHARMACEUT PHARMACOL,CTR BIOMED,BOX 591 S-75124 UPPSALA SWEDEN UPPSALA UNIV,DEPT PHARMACEUT PHARMACOL,CTR BIOMED S-75124 UPPSALA SWEDEN LATVIAN ACAD SCI,INST ORGAN SYNTH,PHARMACOL LAB LV-226006 RIGA LATVIA WA PHARM UMEA SWEDEN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 314, anno: 1996,
pagine: 381 - 384
SICI:
0014-2999(1996)314:3<381:ATICFT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; EXPRESSION; START; GENE; MSH;
Keywords:
MELANOCORTIN MC(3) RECEPTOR; MSH (MELANOCYTE-STIMULATING HORMONE); LIGAND BINDING; MUTAGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
H.B. Schioth et al., "ALTERNATIVE TRANSLATION INITIATION CODON FOR THE HUMAN MELANOCORTIN MC(3) RECEPTOR DOES NOT AFFECT THE LIGAND-BINDING", European journal of pharmacology, 314(3), 1996, pp. 381-384

Abstract

The genomic DNA for the human melanocortin MC(3) receptor indicates an unusually long N-terminus. Two possible translation initiation sites, the one originally proposed and one alternate 111 bp downstream, were mutated, For a third mutant the DNA between these initiation sites was deleted. All mutants were expressed in COS (CV-1 Origin, SV40) cells in the same level, and they bound peptide hormones in the same fashion, as did the wild type clone. The data obtained indicate that both sites can function as the sole translation initiation sites of the human clone and that the proposed N-terminus of the human melanocortin MC(3) receptor is not important for the ligand binding of the receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:54:14