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Titolo:
LACK OF EMODIN GENOTOXICITY IN THE MOUSE MICRONUCLEUS ASSAY
Autore:
MENGS U; KRUMBIEGEL G; VOLKNER W;
Indirizzi:
MADAUS AG,OSTMERHEIMER STR 198 D-51109 COLOGNE GERMANY CCR,CYTOTEST CELL RES D-64380 ROSSDORF GERMANY
Titolo Testata:
Mutation research. Genetic toxicology and environmental mutagenesis
fascicolo: 3, volume: 393, anno: 1997,
pagine: 289 - 293
SICI:
1383-5718(1997)393:3<289:LOEGIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRYSAZIN; SENNA;
Keywords:
EMODIN; ANTHRAQUINONE; GENOTOXICITY; MICRONUCLEUS ASSAY; IN VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
U. Mengs et al., "LACK OF EMODIN GENOTOXICITY IN THE MOUSE MICRONUCLEUS ASSAY", Mutation research. Genetic toxicology and environmental mutagenesis, 393(3), 1997, pp. 289-293

Abstract

The study was performed to investigate the potential of emodin (1,3,8-trihydroxy-6-methylanthraquinone) to induce micronuclei in polychromatic erythrocytes (PCEs). Mice of both genders received a single oral dose of 2000 mg emodin/kg and were killed 24 and 48 h later. Bone marrow cells were collected from 5 males and 5 females and 2000 PCEs per animal were scored for the presence of micronuclei. There was no enhancement in the frequency of micronuclei at both preparation intervals when compared to the negative controls. Blood level examinations confirmed the systemic availability of emodin. Plasma levels of up to 190 mu gemodin/ml represented concentrations being in the concentration rangethat induced positive responses in several genotoxicity cell culture assays. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:31:06