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Titolo:
INFLUENCE OF [4CL-D-PHE(6),LEU(17)]VIP ON VIP-INDUCED AND CENTRAL TRH-INDUCED GASTRIC HYPEREMIA
Autore:
KIRALY A; SUTO G; GUTH P; TACHE Y;
Indirizzi:
W LOS ANGELES VET AFFAIRS MED CTR,CURE DIGEST DIS RES CTR,11301 WILSHIRE BLVD,BLD 115,ROOM 203 LOS ANGELES CA 90073 W LOS ANGELES VET AFFAIRS MED CTR,CURE DIGEST DIS RES CTR LOS ANGELESCA 90073 UNIV CALIF LOS ANGELES,DEPT MED LOS ANGELES CA 90073 UNIV CALIF LOS ANGELES,BRAIN RES INST LOS ANGELES CA 90073
Titolo Testata:
Peptides
fascicolo: 9, volume: 18, anno: 1997,
pagine: 1321 - 1325
SICI:
0196-9781(1997)18:9<1321:IO[OVA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; MUCOSAL BLOOD-FLOW; THYROTROPIN-RELEASING-HORMONE; HYDROGEN GAS CLEARANCE; VAGAL-STIMULATION; RAT; POLYPEPTIDE; ANTAGONIST; SECRETION; RECEPTOR;
Keywords:
VIP; VIP ANTAGONIST; TRH ANALOG; RX 77368; GASTRIC MUCOSAL BLOOD FLOW; BLOOD PRESSURE; VAGUS; GASTRIC VASCULAR RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Kiraly et al., "INFLUENCE OF [4CL-D-PHE(6),LEU(17)]VIP ON VIP-INDUCED AND CENTRAL TRH-INDUCED GASTRIC HYPEREMIA", Peptides, 18(9), 1997, pp. 1321-1325

Abstract

The specific VIP receptor antagonist, [4Cl-D-Phe(6),Leu(17)]VIP, infused iv blocked close-intra-arterial infusion of VIP-induced increase in gastric mucosal blood flow (GMBF, measured by the hydrogen gas clearance), and decrease in mean arterial blood pressure while nor influencing basal levels in urethane-anesthetized rats. The thyrotropin-releasing hormone (TRH) stable analog, RX 77368, injected intracisternally (IC, 30 ng) increased GMBF and blood pressure. The VIP antagonist did not significantly reduce the GMBF response to IC RX 77368 while enhancing the rise in blood pressure. These findings indicate that [4Cl-D-Phe(6),Leu(17)]VIP is an antagonist for exogenous VIP induced gastric hyperemia and hypotension and that VIP modulates the systemic blood pressure response to IC RX 77368 at 30 ng while not playing a primary role in the increase of GMBF. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:11:33