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Titolo:
COMPETITIVE NMDA RECEPTOR ANTAGONIST, CGP-40116, SUBSTITUTES FOR THE DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL
Autore:
BIENKOWSKI P; STEFANSKI R; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,SOBIESKIEGO I-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND MED HIGH SCH,DEPT EXPT & CLIN PHARMACOL WARSAW POLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 314, anno: 1996,
pagine: 277 - 280
SICI:
0014-2999(1996)314:3<277:CNRACS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS;
Keywords:
ETHANOL; NMDA RECEPTOR ANTAGONIST; DRUG DISCRIMINATION; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski et al., "COMPETITIVE NMDA RECEPTOR ANTAGONIST, CGP-40116, SUBSTITUTES FOR THE DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL", European journal of pharmacology, 314(3), 1996, pp. 277-280

Abstract

A drug discrimination procedure was used to compare the ability of competitive (CGP 37849, D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentanoate; CGP 40116, D-(E)-2-amino-4-methyl-5-phosphono-3-pentanoate) and non-competitive (dizocilpine) NMDA receptor antagonists to substitute forethanol in rats trained to discriminate between a 1.0 g/kg dose of ethanol (i.p.) and saline. Dizocilpine (0.1-0.3 mg/kg) substituted partially for ethanol at doses that markedly reduced the rate of responding. CGP 37849 (1.25-5.0 mg/kg) substituted partially for ethanol and suppressed the response rate. CGP 40116 (0.5-2.5 mg/kg), an active D-stereoisomer of CGP 37849, completely substituted (88%) for ethanol, and caused only moderate suppression of the response rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:12:34