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Titolo:
AN SL3-3 MURINE LEUKEMIA-VIRUS ENHANCER VARIANT MORE PATHOGENIC THAN THE WILD-TYPE OBTAINED BY ASSISTED MOLECULAR EVOLUTION IN-VIVO
Autore:
ETHELBERG S; SORENSEN AB; SCHMIDT J; LUZ A; PEDERSEN FS;
Indirizzi:
AARHUS UNIV,DEPT MOL & STRUCT BIOL,CF MOLLERS ALLEE,BLDG 130 DK-8000 AARHUS C DENMARK AARHUS UNIV,DEPT MOL & STRUCT BIOL DK-8000 AARHUS C DENMARK AARHUS UNIV,DEPT MED MICROBIOL & IMMUNOL DK-8000 AARHUS C DENMARK GSF NATL RES CTR ENVIRONM & HLTH,INST MOL VIROL D-85764 NEUHERBERG GERMANY GSF NATL RES CTR ENVIRONM & HLTH,INST PATHOL D-85764 NEUHERBERG GERMANY
Titolo Testata:
Journal of virology
fascicolo: 12, volume: 71, anno: 1997,
pagine: 9796 - 9799
SICI:
0022-538X(1997)71:12<9796:ASMLEV>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
I TRANSCRIPTIONAL ACTIVATORS; RETROVIRUS; SEQUENCES; BINDING; CORE; ELEMENTS; ADJACENT; AML1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
S. Ethelberg et al., "AN SL3-3 MURINE LEUKEMIA-VIRUS ENHANCER VARIANT MORE PATHOGENIC THAN THE WILD-TYPE OBTAINED BY ASSISTED MOLECULAR EVOLUTION IN-VIVO", Journal of virology, 71(12), 1997, pp. 9796-9799

Abstract

SL3-3 is a highly T-lymphomagenic murine retrovirus in which the transcriptional enhancer is a major oncogenic determinant. Here, we describe an SL3-3 enhancer variant that induced T-cell lymphomas in all inoculated mice with a shorter latency period than wild-type SL3-3. The enhancer repeat region of this variant contains two deletions encompassing the nuclear factor 1 binding sites in addition to an additional intact enhancer repeat element. Tumors induced by this variant were T-cell lymphomas, as indicated by T-cell receptor rearrangements, and contained the input provirus enhancer regions. The variant was the result of mutation of specific transcription factor binding sites in the viralenhancer, isolation of rare second-site enhancer variants from the resulting induced tumors, and subsequent restoration of the original first-site mutations of one such variant. We have termed this process assisted molecular evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:21:08