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Titolo:
LATE TREATMENT WITH POLYENE ANTIBIOTICS CAN PROLONG THE SURVIVAL-TIMEOF SCRAPIE-INFECTED ANIMALS
Autore:
DEMAIMAY R; ADJOU KT; BERINGUE V; DEMART S; LASMEZAS CI; DESLYS JP; SEMAN M; DORMONT D;
Indirizzi:
NIAID,PERSISTENT VIRAL DIS LAB,ROCKY MT LABS,NIH,903 S 4TH ST HAMILTON MT 59840 CEA,SERV NEUROVIROL,DEPT RECH MED,SERV SANTE ARMEES F-92265 FONTENAY ROSES FRANCE UNIV DENIS DIDEROT,INST J MONOD,LAB IMMUNODIFFERENCIAT F-75125 PARIS 05 FRANCE
Titolo Testata:
Journal of virology
fascicolo: 12, volume: 71, anno: 1997,
pagine: 9685 - 9689
SICI:
0022-538X(1997)71:12<9685:LTWPAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOST PRION PROTEIN; AMPHOTERICIN-B; AGENT REPLICATION; PRP ACCUMULATION; HAMSTER SCRAPIE; MOUSE SCRAPIE; MS-8209; BRAIN; IDENTIFICATION; NEUROTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R. Demaimay et al., "LATE TREATMENT WITH POLYENE ANTIBIOTICS CAN PROLONG THE SURVIVAL-TIMEOF SCRAPIE-INFECTED ANIMALS", Journal of virology, 71(12), 1997, pp. 9685-9689

Abstract

Amphotericin B (AmB) is one of the few drugs able to prolong survivaltimes in experimental scrapie and delays the accumulation of PrPres, a specific marker of this disease in the brain in vivo. Previous reports showed that the AmB effect is observed only if the drug is administered around the time of infection. In the present study, intracerebrally infected mice mere treated with AmB or one of its derivatives, MS-8209, between 80 and 140 days postinoculation. We observed an increasedincubation time and a delay in PrPres accumulation and glial fibrillary acidic protein gene expression. Treatment starting at 80 days postinoculation was as efficient as long-term treatment starting the day ofinoculation. Our results indicate that polyene antibiotics may interfere, throughout the course of the experimental disease, with the propagation of the scrapie agent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:32:17