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Titolo:
COMPARATIVE GENOMIC HYBRIDIZATION FOR THE ANALYSIS OF CHROMOSOMAL IMBALANCES IN SOLID TUMORS AND HEMATOLOGICAL MALIGNANCIES
Autore:
ZITZELSBERGER H; LEHMANN L; WERNER M; BAUCHINGER M;
Indirizzi:
GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST STRAHLENBIOL,POSTFACH 1129 D-85758 OBERSCHLEISSHEIM GERMANY GSF MUNICH,NATL RES CTR ENVIRONM & HLTH,INST RADIOBIOL NEUHERBERG GERMANY UNIV MUNICH,INST RADIAT BIOL MUNICH GERMANY TECH UNIV MUNICH,INST PATHOL D-8000 MUNICH GERMANY
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 4-5, volume: 108, anno: 1997,
pagine: 403 - 417
SICI:
0948-6143(1997)108:4-5<403:CGHFTA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA COPY NUMBER; MOLECULAR CYTOGENETIC ANALYSIS; SQUAMOUS-CELL CARCINOMAS; ACUTE MYELOID-LEUKEMIA; HYBRIDIZATION ANALYSIS; GENETIC ABERRATIONS; PROSTATE-CANCER; HUMAN SARCOMAS; BREAST-CANCER; LOW-GRADE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
93
Recensione:
Indirizzi per estratti:
Citazione:
H. Zitzelsberger et al., "COMPARATIVE GENOMIC HYBRIDIZATION FOR THE ANALYSIS OF CHROMOSOMAL IMBALANCES IN SOLID TUMORS AND HEMATOLOGICAL MALIGNANCIES", HISTOCHEM C, 108(4-5), 1997, pp. 403-417

Abstract

Comparative genomic hybridisation (CGH) is based on a two-colour, competitive fluorescence in situ hybridisation of differentially labelledtumour and reference DNA to normal metaphase chromosomes. This new technology has made a great impact in molecular tumour pathology due to its possible application to archival specimens and the ability to create copy number karyotypes throughout the whole genome from very small amounts of DNA. If chromosomal imbalances can be correlated with a etiological and clinical features of tumours, CGH could be able to provide new prognostic and diagnostic criteria. CGH findings further providestarting points for the molecular genetic characterisation of alteredchromosomal regions harbouring yet unidentified genes involved in tumorigenesis and tumour progression. An overview of the results of published CGH studies on solid tumours and haematological malignancies is presented. Methodological limitations of the CGH technology are reported, as well as future developments which will improve its use in routine analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:50:06