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Titolo:
CENTRAL NEUROCYTOMA - AN IMMUNOHISTOCHEMICAL, ULTRASTRUCTURAL AND CELL-CULTURE STUDY
Autore:
ISHIUCHI S; TAMURA M;
Indirizzi:
GUNMA UNIV,SCH MED,DEPT PATHOL,3-39-22 SHOWAMACHI MAEBASHI GUMMA 371 JAPAN GUNMA UNIV,SCH MED,DEPT NEUROSURG GUNMA JAPAN
Titolo Testata:
Acta Neuropathologica
fascicolo: 5, volume: 94, anno: 1997,
pagine: 425 - 435
SICI:
0001-6322(1997)94:5<425:CN-AIU>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENTIATION; NEUROBLASTOMA; LOCALIZATION; PROTEIN; ANTIGEN; BRAIN;
Keywords:
CELL CULTURE; CENTRAL NEUROCYTOMA; HISTOGENESIS; ULTRASTRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S. Ishiuchi e M. Tamura, "CENTRAL NEUROCYTOMA - AN IMMUNOHISTOCHEMICAL, ULTRASTRUCTURAL AND CELL-CULTURE STUDY", Acta Neuropathologica, 94(5), 1997, pp. 425-435

Abstract

To clarify the histogenesis and differentiation potential of central neurocytoma, a pathological investigation of seven tumors from three patients was conducted using immunohistochemistry and ultrastructural analysis in addition to systematic in vitro studies. Six tumors were studied immunohistochemically and five were examined ultrastructurally. All cases that were immunostained were positive for synaptophysin in nuclear-free neuropil islands. In five tumors, a few tumor cells, in addition to reactive astrocytes, were positive for glial fibrillary acidic protein (GFAP). Vimentin staining was also positive in a few tumor cells of five specimens. Neurofilament staining was always negative. All cases for which ultrastructure was examined showed various synapticabnormalities. Cultured cells were subdivided into three distinct tumor cell types: neuronal cells which stained for neurofilament proteinswith neurosecretory granules; small flat undifferentiated cells with a high nuclear-cytoplasmic ratio and scant cytoplasmic organelles; andsmall round or multipolar astrocytic cells with 10-nm intermediate filaments which stained for GFAP. Our tissue culture studies disclosed that cultured neurocytoma cells form a cellular mosaic similar to subependymal plate layers that are composed of mitotically active cells, neurons and glia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:20:31