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Titolo:
PROLIFERATING CELL NUCLEAR ANTIGEN - MORE THAN A CLAMP FOR DNA-POLYMERASES
Autore:
JONSSON ZO; HUBSCHER U;
Indirizzi:
UNIV ZURICH IRCHEL,DEPT VET BIOCHEM,WINTERTHURERSTR 190 CH-8057 ZURICH SWITZERLAND UNIV ZURICH IRCHEL,DEPT VET BIOCHEM CH-8057 ZURICH SWITZERLAND
Titolo Testata:
BioEssays
fascicolo: 11, volume: 19, anno: 1997,
pagine: 967 - 975
SICI:
0265-9247(1997)19:11<967:PCNA-M>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; REGULATED GADD45 PROTEIN; RESPONSE GENE MYD118; DOUBLE-STRANDED DNA; REPLICATION FACTOR; S-PHASE; EXCISION-REPAIR; MISMATCH REPAIR; SLIDING CLAMP; LARGE SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
Z.O. Jonsson e U. Hubscher, "PROLIFERATING CELL NUCLEAR ANTIGEN - MORE THAN A CLAMP FOR DNA-POLYMERASES", BioEssays, 19(11), 1997, pp. 967-975

Abstract

DNA metabolic events such as replication, repair and recombination require the concerted action of several enzymes and cofactors. Nature has provided a set of proteins that support DNA polymerases in performing processive, accurate and rapid DNA synthesis. Two of them, the proliferating cell nuclear antigen and its adapter protein replication factor C, cooperate to form a moving platform that was initially thought of only as an anchor point for DNA polymerases delta and epsilon. It now appears that proliferating cell nuclear antigen is also a communication point between a variety of important cellular processes including cell cycle control, DNA replication, nucleotide excision repair, post-replication mismatch repair, base excision repair and at least one apoptotic pathway. The dynamic movement of proliferating cell nuclear antigen on and off the DNA renders this protein an ideal communicator fora variety of proteins that are essential for DNA metabolic events in eukaryotic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:30:22