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Titolo:
FLOW CYTOMETRIC AND GENOTYPIC ANALYSIS OF PRIMARY NON-HODGKINS-LYMPHOMA OF BONE
Autore:
HATORI M; ICHINOHASAMA R; MYERS J; SCHILLER A; KOKUBUN S;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT ORTHOPAED SURG,AOBA KU,1-1 SEIRYO MACHI SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH DENT,DEPT ORAL PATHOL,AOBA KU SENDAI MIYAGI 98077 JAPAN MADIGAN ARMY MED CTR,DEPT PATHOL TACOMA WA 98431 MT SINAI MED CTR,DEPT PATHOL NEW YORK NY 10029
Titolo Testata:
Pathology research and practice
fascicolo: 8, volume: 193, anno: 1997,
pagine: 557 - 564
SICI:
0344-0338(1997)193:8<557:FCAGAO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-LYMPHOMAS; CLINICAL BEHAVIOR; HIGH ENDOTHELIUM; CLONAL EXCESS; PROGNOSIS; GRADE; CELLS;
Keywords:
BONE NEOPLASMS; NON-HODGKINS LYMPHOMA; IMMUNOHISTOCHEMISTRY; 3-COLOR FLOW CYTOMETRY; ADHESION MOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Hatori et al., "FLOW CYTOMETRIC AND GENOTYPIC ANALYSIS OF PRIMARY NON-HODGKINS-LYMPHOMA OF BONE", Pathology research and practice, 193(8), 1997, pp. 557-564

Abstract

Primary malignant lymphoma of bone presents both diagnostic and therapeutic problems. No previous study has addressed the use of flow cytometry in the immunophenotypic evaluations of bone lymphomas. A 41-year-old Japanese female presented with a large lytic lesion in the right femur. Biopsies from the lesion were examined by light microscopy, immunohistochemistry, 3-color flow cytometry and Southern blotting. Microscopic examination showed a diffuse,, noncleaved large cell lymphoma. The lymphoid cells were positive for mature B cell antigens and the phenotype was: CD5(-), CD10(-), CD19(+), 20(+), CD22(+), IgG(+), IgA(-), IgM(-), kappa(-), lambda(+), CD1(-), CD2(-), CD3(-), CD4(-), CD7(-), CD8(-). Southern blot analysis revealed rearranged bands on both heavy-and lambda light-chain genes, in contrast to germline configuration onT cell antigen receptor (beta, gamma and delta) genes. Flow cytometry, in conjunction with morphologic and other molecular techniques, can provide a rapid and accurate means of diagnosing primary lymphoma of bone. In addition, the capabilities of flow cytometry to assess cell properties/constituents can be utilized in detailed analysis of adhesionmolecules and activation antigen which may lead to better prediction of the prognosis of this group of lymphomas, and may provide further important data for the therapeutic decision making process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:04:44