Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ENDOTHELIN-1 SECRETION BY ALVEOLAR MACROPHAGES IN SYSTEMIC-SCLEROSIS
Autore:
ODOUX C; CRESTANI B; LEBRUN G; ROLLAND C; AUBIN P; SETA N; KAHN MF; FIET J; AUBIER M;
Indirizzi:
HOP BICHAT CLAUDE BERNARD,UNITE PNEUMOL,SERV BIOCHIM A,SERV RHEUMATOL,46 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE HOP BICHAT CLAUDE BERNARD,UNITE PNEUMOL,SERV BIOCHIM A,SERV RHEUMATOLF-75877 PARIS 18 FRANCE FAC XAVIER BICHAT,INSERM,U408 PARIS FRANCE HOP ST LOUIS,LAB BIOL HORMONALE PARIS FRANCE HOP PARIS PARIS FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 5, volume: 156, anno: 1997,
pagine: 1429 - 1435
SICI:
1073-449X(1997)156:5<1429:ESBAMI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE FLUID; INTERSTITIAL LUNG-DISEASE; SCLERODERMA; INVOLVEMENT; FIBROSIS; CELLS; INFLAMMATION; FIBROBLASTS; EXPRESSION; ASTHMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C. Odoux et al., "ENDOTHELIN-1 SECRETION BY ALVEOLAR MACROPHAGES IN SYSTEMIC-SCLEROSIS", American journal of respiratory and critical care medicine, 156(5), 1997, pp. 1429-1435

Abstract

Endothelin-1 (ET-1), a potent fibroblast/smooth muscle cells mitogen,has been implicated in the pathogenesis of systemic sclerosis lung disease (SSc). Since monocytes and macrophages are thought to be activated in SSc, we hypothesized that alveolar macrophages (AM) and their precursors blood monocytes from patients with SSc produced more ET-1 than cells from healthy subjects. ET-1 and big ET-l concentrations were measured in plasma, in bronchoalveolar lavage (BAL) fluids and in cell culture supernatants from monocytes and alveolar macrophages derived from 13 patients with definite SSc with lung involvement and from 10 control subjects. Plasma and BAL fluid ET-1 and big ET-1 levels were similar in both controls and patients with SSc. ET-1 and big ET-1 concentrations in unstimulated alveolar macrophage supernatants were similar in both groups. In contrast, LPS-stimulated alveolar macrophages from patients with SSc secreted higher amounts of ET-1 and big ET-1 than control subjects. ET-1 and big ET-1 concentrations in monocyte supernatants (either LPS-stimulated or not) were not different in patients and controls. These results show that AM from patients with SSc are hyperresponsive to LPS in vitro in terms of ET-1 and big ET-1 production andsuggest that AM could participate in vivo in the overproduction of this potentially profibrotic mediator in patients with SSc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:08:30