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Titolo:
CHARACTERIZATION OF GPI2A, A POTENT INHIBITOR OF HIV-1 GENE-EXPRESSION AND VIRAL REPLICATION
Autore:
ANAZODO MI; DUTA E; SALOMON H; FRIESEN AD; WAINBERG MA; WRIGHT JA;
Indirizzi:
UNIV MANITOBA,MANITOBA INST CELL BIOL WINNIPEG MB R3E 0V9 CANADA UNIV MANITOBA,MANITOBA INST CELL BIOL WINNIPEG MB R3E 0V9 CANADA UNIV MANITOBA,DEPT BIOCHEM & MOL BIOL WINNIPEG MB R3E 0V9 CANADA MCGILL AIDS CTR MONTREAL PQ H3T 1E2 CANADA GENESYS PHARMA INC WINNIPEG MB R3P 1P4 CANADA
Titolo Testata:
Nucleosides & nucleotides
fascicolo: 7-9, volume: 16, anno: 1997,
pagine: 1241 - 1249
SICI:
0732-8311(1997)16:7-9<1241:COGAPI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; REGION; GENOME; GROWTH; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Anazodo et al., "CHARACTERIZATION OF GPI2A, A POTENT INHIBITOR OF HIV-1 GENE-EXPRESSION AND VIRAL REPLICATION", Nucleosides & nucleotides, 16(7-9), 1997, pp. 1241-1249

Abstract

Fully thioated antisense molecules are often cytotoxic and non-specific in action. GPI2A is thioated at 7 base positions. GPI2A posses sequence-specific activity against HIV-1 gene expression and viral replication without significant cytotoxicity. Partial thioation did not compromise its uptake, cellular distribution and nuclease resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:14:54