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Titolo:
BORNA-DISEASE VIRUS IS NOT SENSITIVE TO AMANTADINE
Autore:
HALLENSLEBEN V; ZOCHER M; STAEHELI P;
Indirizzi:
UNIV FREIBURG,DEPT VIROL,INST MED MICROBIOL & HYG,HERMANN HERDER STR 11 D-79008 FREIBURG GERMANY UNIV FREIBURG,DEPT VIROL,INST MED MICROBIOL & HYG D-79008 FREIBURG GERMANY
Titolo Testata:
Archives of virology
fascicolo: 10, volume: 142, anno: 1997,
pagine: 2043 - 2048
SICI:
0304-8608(1997)142:10<2043:BVINST>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; HUMAN INFECTIONS; RNA; PROTEIN; EXPRESSION; ANTIBODIES; SEQUENCE; BDV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
V. Hallensleben et al., "BORNA-DISEASE VIRUS IS NOT SENSITIVE TO AMANTADINE", Archives of virology, 142(10), 1997, pp. 2043-2048

Abstract

Successful inhibition of Borna disease virus (BDV) by amantadine in cultured cells and in an infected human individual has been reported [Bode et al. (1997) Lancet 349: 178-179]. We now found that infection ofmonkey Vero cells by laboratory strains of BDV was not influenced by amantadine under conditions that reduced the yields of influenza A virus by about 400 fold. Amantadine treatment of Vero cells persistently infected with BDV did not result in reduced viral RNA levels, and application of the drug to persistently infected BALB/c mice had no effecton the concentration of BDV in their brains. Thus. susceptibility to amantadine is not a characteristic of BDV, although it may be observedwith certain primary virus isolates.

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Documento generato il 22/01/20 alle ore 21:53:49