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Titolo:
NOVEL INSIGHTS INTO HISTAMINE H-2-RECEPTOR BIOLOGY
Autore:
DELVALLE J; GANTZ I;
Indirizzi:
UNIV MICHIGAN,DIV GASTROENTEROL,DEPT SURG,MED CTR,6520 MSRBI BOX 0682ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED ANN ARBOR MI 48109
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 5, volume: 36, anno: 1997,
pagine: 987 - 996
SICI:
0193-1857(1997)36:5<987:NIIHHB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC-RECEPTOR; SITE-DIRECTED MUTAGENESIS; SIGNAL-TRANSDUCTION PATHWAYS; CELL-LINE MKN-45; PROTEIN-KINASE-C; PIG DISTAL COLON; ADENYLATE-CYCLASE; CYCLIC-AMP; HUMAN HISTAMINE-H2-RECEPTOR; BETA-2-ADRENERGIC RECEPTOR;
Keywords:
BIOGENIC AMINE; G PROTEIN; SIGNAL TRANSDUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
108
Recensione:
Indirizzi per estratti:
Citazione:
J. Delvalle e I. Gantz, "NOVEL INSIGHTS INTO HISTAMINE H-2-RECEPTOR BIOLOGY", American journal of physiology: Gastrointestinal and liver physiology, 36(5), 1997, pp. 987-996

Abstract

Histamine exerts multiple biological actions through one of three receptor subtypes (H-1, H-2, and H-3). This review focuses on new developments regarding the structure and function of the H-2 receptor. In addition to the important role this receptor plays in stimulating gastricacid secretion, recent studies have demonstrated that it is also involved in regulating gastrointestinal motility and intestinal secretion. The potential role of the H-2 receptor in regulating cell growth and differentiation has also been added to the list of actions this biogenic amine may exert in both normal and transformed tissues. Molecular cloning of the gene indicates that it has the structural characteristics of a heptahelical G protein-linked receptor. Site-directed mutagenesis studies of this receptor reveal the presence of key amino acids within the third and fifth transmembrane domains that are critical for ligand recognition. Molecular approaches have also shed light on the structural components of the H-2 receptor important in regulating desensitization and internalization. Although the H-2 receptor was classically thought to couple to the adenylate cyclase pathway, recent work withthe cloned receptor indicates that it can also activate the phosphoinositide signaling cascade through an independent G protein-dependent mechanism. The novel observation that histamine may stimulate c-fos gene expression lends further support to the possible role of this receptor in regulating cell growth and differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:31:36