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Titolo:
EFFECT OF TANNIC-ACID ON BENZO[A]PYRENE-DNA ADDUCT FORMATION IN MOUSEEPIDERMIS - COMPARISON WITH SYNTHETIC GALLIC ACID-ESTERS
Autore:
BAERDUBOWSKA W; GNOJKOWSKI J; FENRYCH W;
Indirizzi:
KARL MARCINKOWSKI UNIV,SCH MED,DEPT PHARMACEUT BIOCHEM,GRUNWALDZKA 6 PL-60780 POZNAN POLAND
Titolo Testata:
Nutrition and cancer
fascicolo: 1, volume: 29, anno: 1997,
pagine: 42 - 47
SICI:
0163-5581(1997)29:1<42:EOTOBA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCCURRING PLANT PHENOLS; SKIN TUMOR INITIATION; SENCAR MICE; HYDROCARBON METABOLISM; PROPYL GALLATE; DNA-BINDING; INHIBITION; ANTIOXIDANTS; FORESTOMACH; CARCINOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
W. Baerdubowska et al., "EFFECT OF TANNIC-ACID ON BENZO[A]PYRENE-DNA ADDUCT FORMATION IN MOUSEEPIDERMIS - COMPARISON WITH SYNTHETIC GALLIC ACID-ESTERS", Nutrition and cancer, 29(1), 1997, pp. 42-47

Abstract

Tannic acid, a naturally occurring plant phenol, was shown to inhibitthe mutagenicity and/or tumorigenicity of several polycyclic aromatichydrocarbons in mouse skin. In this study the effect of topical application of tannic acid on epidermal aryl hydrocarbon hydroxylase, glutathione S-transferase, and binding of benzo[a]pyrene (B[a]P) to epidermal DNA was compared with the activity of synthetic gallic acid esters. Single topical application of 8 mu mol octyl and dodecyl gallate had no effect on the induction of aryl hydrocarbon hydroxylase, whereas propyl gallate and tannic acid increased the enzyme activity by nearly 200%. Application of the phenolics one hour before 0.2 mu mol of B[a]P enhanced the enzyme activity, but the observed differences were not significant in comparison with a B[a]P-treated group of mice. Application of dodecyl and octyl gallates to mouse skin resulted in three-and twofold increases, respectively, in the activity of glutathione S-transferase. Combined treatment with dodecyl gallate and B[a]P also resultedin significant enhancement of this enzyme activity. Application of the same dose of tannic acid to mouse skin one hour before the application of 0.2 or 1 mu mol of B[a]P afforded 60% inhibition of covalent benzo[a]pyrene-diol-epoxide binding to epidermal DNA. Gallic acid esters with the exception of dodecyl gallate were less effective inhibitors of benzo[a]pyrene-diol-epoxide binding, especially when the higher doseof B[a]P was used. These results indicate that the antitumorigenic activity of tannic acid involves the interaction of the ultimate carcinogen with DNA rather than an altered metabolism. The linkage between gallic acid and glucose in natural plant phenols is also more effective at inhibiting B[a]P binding to epidermal DNA than the linkage with thealkyl group in synthetic gallates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:48:00