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Titolo:
PARANEOPLASTIC MYASTHENIA-GRAVIS - DETECTION OF ANTI-MGT30 (TITIN) ANTIBODIES PREDICTS THYMIC EPITHELIAL TUMOR
Autore:
VOLTZ RD; ALBRICH WC; NAGELE A; SCHUMM F; WICK M; FREIBURG A; GAUTEL M; THALER HT; AARLI J; KIRCHNER T; HOHLFELD R;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT BIOSTAT & EPIDEMIOL NEW YORK NY 10021 UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL MUNICH GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT CLIN CHEM MUNICH GERMANY EMBL HEIDELBERG GERMANY UNIV ERLANGEN NURNBERG,DEPT PATHOL D-8520 ERLANGEN GERMANY UNIV BERGEN,DEPT NEUROL N-5014 BERGEN NORWAY
Titolo Testata:
Neurology
fascicolo: 5, volume: 49, anno: 1997,
pagine: 1454 - 1457
SICI:
0028-3878(1997)49:5<1454:PM-DOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Voltz et al., "PARANEOPLASTIC MYASTHENIA-GRAVIS - DETECTION OF ANTI-MGT30 (TITIN) ANTIBODIES PREDICTS THYMIC EPITHELIAL TUMOR", Neurology, 49(5), 1997, pp. 1454-1457

Abstract

It has been suggested that antibodies against nonacetylcholine receptor proteins of striated muscle are markers of the presence of a thymicepithelial tumor in patients with myasthenia gravis (MG). These antibodies may be? measured using an immunofluorescence assay against striated muscle (anti-STR) or an ELISA with a recombinant 30-kd titin fragment (anti-MGT30). To directly compare anti-STR with anti-MGT30, we examined the sera of 276 consecutive patients with known or suspected MG. Definite diagnoses and thymic histology, if available, were correlated with the antibody assays. Of the 276 patients, 164 had MG. Thymic histology was obtained in 44 patients: 18 had lymphofollicular hyperplasia, 13 thymic epithelial tumors, 8 atrophy, and 5 were normal. When compared with anti-STR, anti-MGT30 showed a sensitivity of 69% (STR 77%), specificity or 100% (STR 56%, p = 0.026), negative predictive value or 82% (STR 77%), and positive predictive value of 100% (STR 56%, p = 0.003) for the identification of a thymic epithelial tumor versus thymic hyperplasia. We conclude that the anti-MGT30 ELISA is better than the anti-STR immunofluorescence assay for the diagnosis of paraneoplastic MG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:57:03