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Titolo:
MPTP INDUCES DYSTONIA AND PARKINSONISM - CLUES TO THE PATHOPHYSIOLOGYOF DYSTONIA
Autore:
PERLMUTTER JS; TEMPEL LW; BLACK KJ; PARKINSON D; TODD RD;
Indirizzi:
CAMPUS BOX 8225,4525 SCOTT AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROL SURG NEUROL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,MALLINCKRODT INST RADIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT CELL BIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
Neurology
fascicolo: 5, volume: 49, anno: 1997,
pagine: 1432 - 1438
SICI:
0028-3878(1997)49:5<1432:MIDAP->2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPA-RESPONSIVE DYSTONIA; CAROTID-ARTERY INFUSION; BASAL GANGLIA; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; PRIMATE MODEL; IDIOPATHIC DYSTONIA; GENE-EXPRESSION; WRITERS CRAMP; HEMIPARKINSONISM; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Perlmutter et al., "MPTP INDUCES DYSTONIA AND PARKINSONISM - CLUES TO THE PATHOPHYSIOLOGYOF DYSTONIA", Neurology, 49(5), 1997, pp. 1432-1438

Abstract

The pathophysiology of dystonia is unclear, but several clues implicate striatal dopamine dysfunction. In contrast, the causal relationshipbetween striatal dopamine deficiency and parkinsonism is well defined. We now suggest that parkinsonism or dystonia may occur following striatal dopamine deficiency. Baboons treated with intracarotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) developed transient hemidystonia prior to hemiparkinsonism. The day after MPTP treatment, most animals had spontaneous ipsilateral turning. Within a few days, all developed contralateral hemidystonia, with the arm and leg extended and externally rotated. This transient dystonia preceded hemiparkinsonism with flexed posture, bradykinesia, and postural tremor that persisted for up to 1.5 years. Dystonia corresponded temporally with a decreased striatal dopamine content and a transient decrease in D-2-like receptornumber. The time course of dystonia and parkinsonism is analogous to lower limb dystonia as the first, frequently transient, symptom of Parkinson's disease in humans. The association of striatal dopamine deficiency with dystonia and parkinsonism implies that other factors influence clinical manifestations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:09:06