Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMPAIRED MOTOR CORTEX INHIBITION IN PATIENTS WITH AMYOTROPHIC-LATERAL-SCLEROSIS - EVIDENCE FROM PAIRED TRANSCRANIAL MAGNETIC STIMULATION
Autore:
ZIEMANN U; WINTER M; REIMERS CD; REIMERS K; TERGAU F; PAULUS W;
Indirizzi:
NINCDS,HUMAN MOTOR CONTROL SECT,MED NEUROL BRANCH,NIH,BLDG 10,ROOM 5N242,10 CTR DR BETHESDA MD 20892 UNIV GOTTINGEN,DEPT CLIN NEUROPHYSIOL D-37075 GOTTINGEN GERMANY
Titolo Testata:
Neurology
fascicolo: 5, volume: 49, anno: 1997,
pagine: 1292 - 1298
SICI:
0028-3878(1997)49:5<1292:IMCIIP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STIMULATION; CORTICAL EXCITABILITY; UNIT RESPONSES; SILENT PERIOD; CORTICOCORTICAL INHIBITION; GENERALIZED EPILEPSY; PARKINSONS-DISEASE; COIL ORIENTATION; CONTROLLED TRIAL; NEURON DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
U. Ziemann et al., "IMPAIRED MOTOR CORTEX INHIBITION IN PATIENTS WITH AMYOTROPHIC-LATERAL-SCLEROSIS - EVIDENCE FROM PAIRED TRANSCRANIAL MAGNETIC STIMULATION", Neurology, 49(5), 1997, pp. 1292-1298

Abstract

We investigated 14 patients with amyotrophic lateral sclerosis (ALS) by paired conditioning-test transcranial magnetic stimulation to test the hypothesis that the motor cortex is hyperexcitable in ALS. Intracortical (corticocortical) inhibition was significantly less in ALS group than in an age-matched healthy control group (85.3 +/- 27.0% versus 45.2 +/- 15.5%, respectively; p < 0.0001). In contrast, intracortical facilitation, motor threshold, and cortical silent period duration in the ALS patients were not different from the control group. We suggestthat the selective abnormality of intracortical inhibition is best compatible with an impaired function of inhibitory interneuronal circuits in the motor cortex than in turn renders the corticomotoneuron hyperexcitable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 10:58:50