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Titolo:
MOLECULAR-BASIS OF T-CELL DYSFUNCTION IN MELANOMA
Autore:
BECKER JC; TERHEYDEN P; BROCKER EB;
Indirizzi:
UNIV WURZBURG,DEPT DERMATOL,JOSEF SCHNEIDER STR 2,BLDG 13 D-97080 WURZBURG GERMANY
Titolo Testata:
Melanoma research
, volume: 7, anno: 1997, supplemento:, 2
pagine: 51 - 57
SICI:
0960-8931(1997)7:<51:MOTDIM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; SIGNAL-TRANSDUCTION MOLECULES; PROTEIN-TYROSINE KINASE; RECEPTOR ZETA-CHAIN; HUMAN GENE MAGE-1; BEARING MICE; MALIGNANT-MELANOMA; INTERLEUKIN-2 GENE; IN-VIVO; ANTIGEN;
Keywords:
MELANOMA; T CELL; TYROSINE KINASE; TRANSCRIPTION FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Becker et al., "MOLECULAR-BASIS OF T-CELL DYSFUNCTION IN MELANOMA", Melanoma research, 7, 1997, pp. 51-57

Abstract

Human melanoma is an immunogenic tumour which is characterized by a number of defined tumour-associated antigens and a specific T-cell-mediated immune response. Nevertheless, there is only limited evidence foran effective antitumour immune response able to eradicate establishedmelanoma. Thus, the existence of an immunologically suppressed state in the tumour-bearing host has become an axiom in tumour immunology. There is increasing evidence that abnormalities in signal transduction events involved in cell activation are the molecular basis for the observed T-cell dysfunction. These abnormalities include altered patternsof protein tyrosin phosphorylation, decreased protein levels of the Src-family kinases p56(lck) and p59(fyn), and of the CD3 zeta chain. Furthermore, differences in the expression of transcription factors of the nuclear factor NF-kappa B/Rel family have been described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:27:31