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Titolo:
NONADRENERGIC-NONCHOLINERGIC RELAXATIONS OF ISOLATED CIRCULAR MUSCLE FROM SOUTH-AMERICAN OPOSSUM ESOPHAGOGASTRIC JUNCTION - IS NITRIC-OXIDETHE INHIBITORY MEDIATOR
Autore:
MATSUDA NM; LEMOS MC; FEITOSA RL; DEOLIVEIRA RB; BALLEJO G;
Indirizzi:
UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FARMACOL BR-14049900 RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FARMACOL BR-14049900 RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT CLIN MED RIBEIRAO PRET SP BRAZIL
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 3, volume: 66, anno: 1997,
pagine: 119 - 125
SICI:
0165-1838(1997)66:3<119:NROICM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER ESOPHAGEAL SPHINCTER; INTERNAL ANAL-SPHINCTER; RAT GASTRIC FUNDUS; VASOACTIVE INTESTINAL POLYPEPTIDE; CANINE ILEOCOLONIC JUNCTION; NONVASCULAR SMOOTH-MUSCLE; NEURONAL NADPH DIAPHORASE; NANC NERVE-STIMULATION; NEUROTRANSMITTER; RESPONSES;
Keywords:
ESOPHAGOGASTRIC JUNCTION; CIRCULAR MUSCLE RELAXATIONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITORS; NITRIC OXIDE INACTIVATORS; NONADRENERGIC-NONCHOLINERGIC NERVES; SOUTH AMERICAN OPOSSUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N.M. Matsuda et al., "NONADRENERGIC-NONCHOLINERGIC RELAXATIONS OF ISOLATED CIRCULAR MUSCLE FROM SOUTH-AMERICAN OPOSSUM ESOPHAGOGASTRIC JUNCTION - IS NITRIC-OXIDETHE INHIBITORY MEDIATOR", Journal of the autonomic nervous system, 66(3), 1997, pp. 119-125

Abstract

Nonadrenergic-noncholinergic (NANC) inhibitory nerves are responsiblefor most of the nerve induced relaxations of gastrointestinal muscle. It has recently been proposed that NANC nerves may release nitric oxide (NO) or a related compound derived from L-arginine. We have recently shown that the South American (SA) opossum is another suitable modelto elucidate the mechanism involved in these NANC relaxations. In thepresent study the effect of NO synthase inhibitors as well as NO inactivators on the NANC-nerve induced relaxations of the circular muscle of the esophagogastric junction (EGJ) of the SA opossum was investigated. It was observed that the NO synthase inhibitors, L-NOARG and L-NAME, caused a concentration-dependent reduction of NANC-nerve induced relaxations which was reversed by L-but not D-arginine. The NO-donors sodium nitroprusside and hydroxilamine as well as NO caused concentration-dependent relaxations of the EGJ circular muscle. In the myenteric plexus of this region, NADPH-diaphorase positive neurons and nerve fibers were observed while in the circular muscle layer only numerous positive fibers were found. The NO inactivators, hydroquinone, pyrogallol and carboxy-PTIO, reduced NO-induced relaxations but failed to affect NANC nerve-and sodium nitroprusside-induced relaxations. Taken together, these findings indicate that NANC nerve induced relaxation of the SA opossum EGJ circular muscle is dependent on neural NO synthase activity and suggest that the neurotransmitter being released is a superoxide resistant molecule, which is unlikely to be the NO radical, or thatthe activity of NO synthase is required for the release of the actualneurotransmitter rather than for synthesizing the neuromediator. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 11:40:48