Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
U-50,488H, A SELECTIVE KAPPA-OPIOID RECEPTOR AGONIST, AMELIORATES MEMORY IMPAIRMENTS INDUCED BY MUSCARINIC AUTORECEPTOR AGONIST, CARBACHOL IN MICE
Autore:
HIRAMATSU M; HYODO T; KAMEYAMA T;
Indirizzi:
MEIJO UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TEMPAKU KU NAGOYA AICHI 468 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 236, anno: 1997,
pagine: 45 - 48
SICI:
0304-3940(1997)236:1<45:UASKRA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL MOSSY FIBERS; INDUCED DELAYED AMNESIA; RAT NUCLEUS-ACCUMBENS; ACETYLCHOLINE-RELEASE; MEDIATED INHIBITION; ALZHEIMERS-DISEASE; DYNORPHIN A-(1-13); GUINEA-PIG; BRAIN; DOPAMINE;
Keywords:
U-50,488H; KAPPA OPIOID RECEPTOR AGONIST; CARBACHOL; MUSCARINIC AUTORECEPTOR; LEARNING AND MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Hiramatsu et al., "U-50,488H, A SELECTIVE KAPPA-OPIOID RECEPTOR AGONIST, AMELIORATES MEMORY IMPAIRMENTS INDUCED BY MUSCARINIC AUTORECEPTOR AGONIST, CARBACHOL IN MICE", Neuroscience letters, 236(1), 1997, pp. 45-48

Abstract

We investigated whether carbachol, a muscarinic receptor agonist, induces learning and memory impairments, and U-50,488H, a selective kappaopioid receptor agonist, ameliorates the impairments of learning and memory using a step-down type passive avoidance task in mice. Carbachol induced a dose-related dual response, Carbachol (3 nmol/mouse, i.c.v.) significantly shortened the step-down latency, while lower (1 nmol)and higher (10 nmol) doses of carbachol did not induce learning and memory impairments. U-50,488H (0.64 mu mol/kg, s.c.) significantly improved carbachol-induced impairments of learning and memory. These findings suggest that kappa opioid receptor agonists ameliorate learning and memory impairments which may associate with dysfunction of presynaptic cholinergic neurons. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:48:08