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Titolo:
INTERSTITIAL LASER THERMOTHERAPY OF ADENOCARCINOMA TRANSPLANTED INTO RAT-LIVER
Autore:
MOLLER PH; IVARSSON K; STENRAM U; RADNELL M; TRANBERG KG;
Indirizzi:
LUND UNIV,DEPT SURG S-22185 LUND SWEDEN LUND UNIV,DEPT PATHOL S-22185 LUND SWEDEN
Titolo Testata:
The European journal of surgery
fascicolo: 11, volume: 163, anno: 1997,
pagine: 861 - 870
SICI:
1102-4151(1997)163:11<861:ILTOAT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ND-YAG LASER; LOCAL HYPERTHERMIA; RIF-1 TUMOR; PHOTOCOAGULATION; CELLS; METASTASES; NEODYMIUM; SYSTEM; FIBER; PROBE;
Keywords:
NEOPLASM; LASER; HYPERTHERMIA; INTERSTITIAL; LIGHT PENETRATION; FEEDBACK CONTROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P.H. Moller et al., "INTERSTITIAL LASER THERMOTHERAPY OF ADENOCARCINOMA TRANSPLANTED INTO RAT-LIVER", The European journal of surgery, 163(11), 1997, pp. 861-870

Abstract

Objective: To examine the effect of different temperatures and exposure times in interstitial laser thermotherapy. Design: Controlled laboratory study. Setting: University hospital, Sweden. Material: 48 male Wistar FU rats with dimethylhydrazine-induced adenocarcinoma transplanted into the liver. Intervention: Treatment was given with an Nd:YAG laser and a feedback system for temperature regulation. Light was delivered into the centre of the tumour and the feedback thermistor probe was placed 3 mm from the tumour margin. Rats were treated at steady-state temperatures at the feedback thermistor of 43, 46, or 50 degrees C for 30 minutes, and at a steady-state temperature of 46 degrees C at the feedback thermistor also for 10 and 20 minutes. Main outcome measurement: Tumour control as assessed 6 days after treatment using light microscopical examination including immunohistochemical determination ofbromodeoxyuridine (BrdU) incorporation into DNA as a measure of cell viability. Results: Complete tumour necrosis was achieved in all rats treated for 30 minutes, in 6/8 rats treated for 10 minutes and in 6/8 rats treated for 20 minutes at 46 degrees C. During steady-state thermotherapy, temperatures at the tumour margin were about 11 degrees higher than at the feedback thermistor (range 54-61 degrees C). The surrounding liver tissue also became necrotic so that the total necrosis volume exceeded the pretreatment tumour volume. Conclusion: Interstitial laser thermotherapy at temperatures ranging from 54-61 degrees C at the tumour margin ensures total necrosis of a transplanted rat liver carcinoma provided that treatment is given for 30 minutes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:10:18