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Titolo:
COGNITIVE DEFICIT IN 7-YEAR-OLD CHILDREN WITH PRENATAL EXPOSURE TO METHYLMERCURY
Autore:
GRANDJEAN P; WEIHE P; WHITE RF; DEBES F; ARAKI S; YOKOYAMA K; MURATA K; SORENSEN N; DAHL R; JORGENSEN PJ;
Indirizzi:
ODENSE UNIV,INST COMMUNITY HLTH,WINSLOWPK 17 DK-5000 ODENSE DENMARK BOSTON UNIV,SCH MED,DEPT NEUROL BOSTON MA 02118 BOSTON UNIV,SCH MED,DEPT ENVIRONM HLTH BOSTON MA 02118 BOSTON UNIV,SCH PUBL HLTH,DEPT NEUROL BOSTON MA 02118 BOSTON UNIV,SCH PUBL HLTH,DEPT ENVIRONM HLTH BOSTON MA 02118 FAROESE HOSP SYST,DEPT OCCUPAT & PUBL HLTH FR-100 TORSHAVN FAROE ISL DENMARK BOSTON DEPT VET AFFAIRS MED CTR,ENVIRONM HAZARDS CTR BOSTON MA 02130 BOSTON DEPT VET AFFAIRS MED CTR,DEPT PSYCHOL BOSTON MA 02130 UNIV TOKYO,FAC MED,DEPT PUBL HLTH TOKYO 113 JAPAN ODENSE UNIV HOSP,INST CLIN RES DK-5000 ODENSE DENMARK
Titolo Testata:
Neurotoxicology and teratology
fascicolo: 6, volume: 19, anno: 1997,
pagine: 417 - 428
SICI:
0892-0362(1997)19:6<417:CDI7CW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-UTERO EXPOSURE; MINAMATA-DISEASE; POLYCHLORINATED-BIPHENYLS; UMBILICAL-CORD; SEAFOOD DIET; HUMAN-MILK; MERCURY; LEAD; OUTCOMES; SELENIUM;
Keywords:
ENVIRONMENTAL POLLUTION; FOOD CONTAMINATION; METHYLMERCURY COMPOUNDS; NEUROPSYCHOLOGICAL TESTS; PRENATAL EXPOSURE DELAYED EFFECTS; PRESCHOOL CHILD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
P. Grandjean et al., "COGNITIVE DEFICIT IN 7-YEAR-OLD CHILDREN WITH PRENATAL EXPOSURE TO METHYLMERCURY", Neurotoxicology and teratology, 19(6), 1997, pp. 417-428

Abstract

A cohort of 1022 consecutive singleton births was generated during 1986-1987 in the Faroe Islands. Increased methylmercury exposure from maternal consumption of pilot whale meat was indicated by mercury concentrations in cord blood and maternal hair. At approximately 7 years of age, 917 of the children underwent detailed neurobehavioral examination. Neuropsychological tests included Finger Tapping; Hand-Eye Coordination; reaction time on a Continuous Performance Test; Wechsler Intelligence Scale for Children-Revised Digit Spans, Similarities, and Block Designs; Bender Visual Motor Gestalt Test; Boston Naming Test; and California Verbal Learning Test (Children). Clinical examination and neurophysiological testing did not reveal any clear-cut mercury-related abnormalities. However, mercury-related neuropsychological dysfunctions were most pronounced in the domains of lan guage, attention, and memory, and to a lesser extent in visuospatial and motor functions. These associations remained after adjustment for covariates and after exclusion of children with maternal hair mercury concentrations above 10 mu g/g (50 nmol/g). The effects on brain function associated with prenatalmethylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:11:10