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Titolo:
LANGERHANS CELLS REQUIRE SIGNALS FROM BOTH TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA FOR MIGRATION
Autore:
CUMBERBATCH M; DEARMAN RJ; KIMBER I;
Indirizzi:
ZENECA CENT TOXICOL LAB,ALDERLEY PK MACCLESFIELD SK10 4TJ CHESHIRE ENGLAND
Titolo Testata:
Immunology
fascicolo: 3, volume: 92, anno: 1997,
pagine: 388 - 395
SICI:
0019-2805(1997)92:3<388:LCRSFB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRAINING LYMPH-NODES; INTERCELLULAR-ADHESION MOLECULE-1; DENDRITIC CELLS; CONTACT SENSITIZATION; IMMUNE-RESPONSES; FACTOR RECEPTOR; E-CADHERIN; FLUORESCEIN ISOTHIOCYANATE; CYTOKINE RECEPTORS; ICAM-1 EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Cumberbatch et al., "LANGERHANS CELLS REQUIRE SIGNALS FROM BOTH TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA FOR MIGRATION", Immunology, 92(3), 1997, pp. 388-395

Abstract

The induction phase of contact sensitization is associated with the movement of epidermal Langerhans cells (LC) from the skin and their migration, via afferent lymphatics, to draining lymph nodes where they accumulate as immunostimulatory dendritic cells (DC). It has been demonstrated previously that tumour necrosis factor-alpha (TNF-alpha) provides an important signal for LC migration and that in the absence of this cytokine, movement of LC from the epidermis to regional lymph nodes is inhibited. Recent evidence indicates that interleukin-1 beta (IL-1 beta), a cytokine produced in murine epidermis exclusively by LC, may also play a role in LC migration. The purpose of the investigations described here was to clarify, using relevant neutralizing anticytokine antibodies, the contributions made by TNF-alpha and IL-1 beta to the migration of LC from the epidermis. It was found that like anti-TNF-alpha, anti-IL-1 beta administered systemically to mice (by intraperitoneal injection), prior to skin sensitization with the contact allergen oxazolone, resulted in a marked inhibition of DC accumulation in draining lymph nodes. It was shown also that anti-IL-1 beta inhibited TNF-alpha-induced LC migration and DC accumulation and that, in similar fashion, the stimulation of LC migration and DC accumulation induced by IL-1 beta was compromised by prior treatment with anti-TNF-alpha. Based upon these data it is proposed that the stimulation of LC migration inresponse to skin sensitization requires the receipt by LC of two independent signals, one provided by TNF-alpha and the other by IL-1 beta. Morphological analyses of LC in epidermal sheets prepared from animals exposed to these cytokines with or without prior systemic treatment with anti-cytokine antibody suggested that the changes induced in LC by TNF-alpha and IL-1 beta may include the altered expression of adhesion molecules and acquisition of the ability to interact with and pass through the basement membrane.

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Documento generato il 25/11/20 alle ore 02:54:56