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Titolo:
ADMINISTRATION OF ANTI-IL-12 ANTIBODY IN-VIVO INHIBITS REJECTION OF ARAT HISTIOCYTOMA AND SUPPRESSES CYTOKINE RESPONSE IN A TUMOR-BEARING HOST
Autore:
RAO KL; VARALAKSHMI C; ALI AM; KHAR A;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Immunology
fascicolo: 3, volume: 92, anno: 1997,
pagine: 381 - 387
SICI:
0019-2805(1997)92:3<381:AOAAII>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL STIMULATORY FACTOR; INTERFERON-GAMMA-PRODUCTION; BLOOD MONONUCLEAR-CELLS; IFN-GAMMA; NK CELLS; T-CELLS; SPONTANEOUS REGRESSION; MONOCLONAL-ANTIBODIES; IN-VIVO; INTERLEUKIN-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
K.L. Rao et al., "ADMINISTRATION OF ANTI-IL-12 ANTIBODY IN-VIVO INHIBITS REJECTION OF ARAT HISTIOCYTOMA AND SUPPRESSES CYTOKINE RESPONSE IN A TUMOR-BEARING HOST", Immunology, 92(3), 1997, pp. 381-387

Abstract

Activated macrophages are the major producers of heterodimeric cytokine interleukin-12 (IL-12). Earlier evidence suggested that early rejection of AK-5 tumours is mediated by IL-12 through interferon-gamma (IFN-gamma) production, involving activation of natural killer (NK) cellsand upregulation of T-heIper 1 (Th1)-type cytokine response. Injection of anti-IL-12 antibody into AK-5 tumour-bearing animals resulted in a large number of changes in the host immune response towards the tumour. These animals showed diminished NK-mediated antibody-dependent cell-mediated cellular cytotoxicity (ADCC) activity, down-regulation of Th1-type cytokine response, decreased antitumour antibody response ultimately leading to either delay or inhibition of the tumour-regression process. There was also increased production of IL-10 in the animals that had received anti-IL-12 antibody thereby resulting in the down-regulation of IL-2 and IFN-gamma production. IL-12 plays a major role in the activation of the different immune parameters responsible for early rejection of AK-5 tumour. We also studied the activation status of macrophages from tumour-transplanted animals and their ability to produce IL-12. Monocytes/macrophages from antibody-injected animals were less active and produced lower quantities of IL-12, IL-I beta and tumournecrosis factor-alpha (TNF-alpha) as compared with the macrophages from AK-5 tumour-bearing animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:05:17