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Titolo:
EFFECTS OF PROGLUMIDE ON CHOLECYSTOKININ-8-INDUCED EXOCRINE AND ENDOCRINE PANCREATIC RESPONSES IN CONSCIOUS SHEEP
Autore:
MINEO H; IWAKI N; KOGISHI K; ONAGA T; KATO S; ZABIELSKI R;
Indirizzi:
RAKUNO GAKUEN UNIV,FAC VET MED EBETSU HOKKAIDO 069 JAPAN AGR UNIV WARSAW,FAC VET MED,DEPT ANIM PHYSIOL PL-02766 WARSAW POLAND
Titolo Testata:
Comparative biochemistry and physiology. Section A: Comparative physiology
fascicolo: 3, volume: 118, anno: 1997,
pagine: 759 - 764
SICI:
1095-6433(1997)118:3<759:EOPOCE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-INHIBITORY POLYPEPTIDE; INSULIN-SECRETION; RECEPTOR ANTAGONISTS; GLUCAGON-SECRETION; INTRAVENOUS INFUSIONS; CCK; RAT; FRAGMENTS; L-364,718; L-364718;
Keywords:
CCK; PROGLUMIDE; ENDOCRINE PANCREAS; EXOCRINE PANCREAS; INSULIN; GLUCAGON; AMYLASE; PANCREATIC JUICE; RUMINANTS; SHEEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
H. Mineo et al., "EFFECTS OF PROGLUMIDE ON CHOLECYSTOKININ-8-INDUCED EXOCRINE AND ENDOCRINE PANCREATIC RESPONSES IN CONSCIOUS SHEEP", Comparative biochemistry and physiology. Section A: Comparative physiology, 118(3), 1997, pp. 759-764

Abstract

The effects of cholecystokinin (CCK)-8, either alone or together withthe CCK antagonist, proglumide on both exocrine and endocrine pancreatic responses were examined in conscious sheep. Intravenous infusions of CCK-8 (120 pmol/kg/min for 40 min) with vehicle (0 mu mol/kg/min proglumide) significantly increased both amylase output in pancreatic juice and plasma insulin concentrations (P < 0.05). Concomitant infusions of proglumide (5-40 mu mol/kg/min for 50 min) inhibited both amylaseand insulin secretory responses induced by CCK-8 infusion. The antagonistic effects of proglumide occurred in a dose-dependent manner, and proglumide infusion at dose of 20 mu mol/kg/min or above simultaneously inhibited CCK-8-induced amylase and insulin responses. In conclusion, although the type of receptor involved is not characterized at present, exogenously infused CCK-8 acts on B cells via a CCK-receptor-mediated mechanism and induces insulin secretion in sheep. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:06:40