Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GLOMERULAR VOLUME AND THE GLOMERULAR VASCULAR POLE AREA IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS
Autore:
OSTERBY R; ASPLUND J; BANGSTAD HJ; NYBERG G; RUDBERG S; VIBERTI GC; WALKER JD;
Indirizzi:
AARHUS KOMMUNE HOSP,INST EXPT CLIN RES,ELECTRON MICROSCOPY LAB,BLDG 03 DK-8000 AARHUS C DENMARK FALU CTY HOSP,DEPT INTERNAL MED FALUN SWEDEN AKER DIABET RES CTR OSLO NORWAY SAHLGRENS UNIV HOSP,TRANSPLANT UNIT S-41345 GOTHENBURG SWEDEN KAROLINSKA INST,PAEDIAT UNIT,DEPT WOMAN & CHILD HLTH STOCKHOLM SWEDEN GUYS HOSP,METAB MED UNIT LONDON SE1 9RT ENGLAND
Titolo Testata:
Virchows Archiv
fascicolo: 5, volume: 431, anno: 1997,
pagine: 351 - 357
SICI:
0945-6317(1997)431:5<351:GVATGV>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FILTRATION RATE; RENAL HYPERTROPHY; NEPHROPATHY; SIZE; MICROALBUMINURIA; ABNORMALITIES; SURFACE;
Keywords:
DIABETIC GLOMERULOPATHY; GLOMERULAR HYPERTROPHY; GLOMERULAR VASCULAR POLE; INSULIN-DEPENDENT DIABETES MELLITUS (IDDM); STEREOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R. Osterby et al., "GLOMERULAR VOLUME AND THE GLOMERULAR VASCULAR POLE AREA IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS", Virchows Archiv, 431(5), 1997, pp. 351-357

Abstract

The vascular pole area (VPA) and glomerular volume were measured in renal biopsies from 9 insulin-dependent diabetes mellitus (IDDM) patients with normal albumin excretion rate (IDDM group 1), 38 IDDM patientswith albumin excretion rate >15 mu g/min (IDDM group 2) and 10 livingkidney donors (ND). The volume of individual glomeruli was estimated as the sum of profile areas factored by the measured distance between levels, t similar to 10 mu m, and VPA as the sum of chords multiplied by t. Mean glomerular volume was increased in IDDM patients but reached statistical significance only in IDDM group 2 (P = 0.002 vs ND). VPAwas significant ly different among the groups, mean (CV%) was 2036 (29) mu m(2) in ND, 3555 (34) mu m(2) in IDDM group 1, and 3528 (48) mu m(2) in IDDM group 2, p = 0.004 and 0.001, IDDM versus ND. VPA calculated as a percentage of the surface area of the corresponding glomerulus was 2.4 (23)% in ND, 3.4 (27)% in IDDM group 1, and 3.3 (32)% in IDDM group 2; P = 0.007 and 0.01, IDDM versus ND. The intra-biopsy coefficient of variation was high (20-35%) and of the same order in all groups for all three measurements. Glomerular volume and absolute as well as relative size of VPA showed a positive correlation with estimates of mesangial expansion in IDDM group 2 and the VPA showed a negative correlation with GFR. Thus, part of the enlargement may represent a compensatory phenomenon triggered by the development of structural and functional abnormalities in the diabetic kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:43:13