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Titolo:
ABNORMAL SULFATE METABOLISM IN VITAMIN-D-DEFICIENT RATS
Autore:
FERNANDES I; HAMPSON G; CAHOURS X; MORIN P; COUREAU C; COUETTE S; PRIE D; BIBER J; MURER H; FRIEDLANDER G; SILVE C;
Indirizzi:
FAC XAVIER BICHAT,INSERM,U426,BP 416,16 RUE HENRI HUCHARD F-75870 PARIS 18 FRANCE FAC XAVIER BICHAT,INSERM,U426 F-75870 PARIS 18 FRANCE UNIV PARIS 07 F-75221 PARIS 05 FRANCE UNIV ORLEANS,INST CHIM ORGAN & ANALYT F-45067 ORLEANS FRANCE UNIV ORLEANS,CNRS,URA 499 F-45067 ORLEANS FRANCE UNIV ZURICH,DEPT PHYSIOL CH-8006 ZURICH SWITZERLAND
Titolo Testata:
The Journal of clinical investigation
fascicolo: 9, volume: 100, anno: 1997,
pagine: 2196 - 2203
SICI:
0021-9738(1997)100:9<2196:ASMIVR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BRUSH-BORDER; CAPILLARY ELECTROPHORESIS; INORGANIC SULFATE; MEMBRANE-VESICLES; THYROID-HORMONE; TRANSPORT; SEPARATION; EXPRESSION; PROTEIN; CATIONS;
Keywords:
VITAMIN-D DEFICIENCY; NA-SO4 COTRANSPORTER; SULFATE HOMEOSTASIS; PARATHYROID HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
I. Fernandes et al., "ABNORMAL SULFATE METABOLISM IN VITAMIN-D-DEFICIENT RATS", The Journal of clinical investigation, 100(9), 1997, pp. 2196-2203

Abstract

To explore the possibility that vitamin D status regulates sulfate homeostasis, plasma sulfate levels, renal sulfate excretion, and the expression of the renal Na-SO4 cotransporter were evaluated in vitamin D-deficient D-D-) rats and in D-D- rats rendered normocalcemic by eithervitamin D or calcium/lactose supplementation. D-D- rats had significantly lower plasma sulfate levels than control animals (0.93 +/- 0.01 and 1.15 +/- 0.05 mM, respectively, P < 0.05), and fractional sulfate renal excretion was approximately threefold higher comparing D-D- and control rats. A decrease in renal cortical brush border membrane Na-SO4cotransport activity, associated with a parallel decrease in both renal Na-SO4 cotransport protein and mRNA content (78 +/- 3 and 73 +/- 3%decreases, respectively, compared with control values), was also observed in D-D- rats. Vitamin D supplementation resulted in a return to normal of plasma sulfate, fractional sulfate excretion, and both renal Na-SO4 cotransport mRNA and protein. In contrast, renal sulfate excretion and renal Na-SO4 cotransport activity, protein abundance, and mRNAremained decreased in vitamin D-depleted rats fed a diet supplementedwith lactose and calcium, despite that these rats were normocalcemic,and had significantly lower levels of parathyroid hormone and 25(OH)and 1,25(0H)(2)-vitamin D levels than the vitamin D-supplemented groups. These results demonstrate that vitamin D modulates renal Na-SO4 sulfate cotransport and sulfate homeostasis. The ability of vitamin D status to regulate Na-SO4 cotransport appears to be a direct effect, and is not mediated by the effects of vitamin D on plasma calcium or parathyroid hormone levels. Because sulfate is required for synthesis of essential matrix components, abnormal sulfate metabolism in vitamin D-deficient animals may contribute to producing some of the abnormalities observed in rickets and osteomalacia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:22:23