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Titolo:
STRONG BALANCING SELECTION AT HLA LOCI - EVIDENCE FROM SEGREGATION INSOUTH AMERINDIAN FAMILIES
Autore:
BLACK FL; HEDRICK PW;
Indirizzi:
ARIZONA STATE UNIV,DEPT BIOL TEMPE AZ 85287 ARIZONA STATE UNIV,DEPT BIOL TEMPE AZ 85287 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06520
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 23, volume: 94, anno: 1997,
pagine: 12452 - 12456
SICI:
0027-8424(1997)94:23<12452:SBSAHL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; NUCLEOTIDE SUBSTITUTION; OVERDOMINANT SELECTION; HUMANS; MHC; POLYMORPHISM; POPULATIONS; ANTIGENS;
Keywords:
HETEROZYGOTE ADVANTAGE; MATERNAL-FETAL INTERACTION; MAJOR HISTOCOMPATIBILITY COMPLEX; POLYMORPHISM; RECIPROCAL MATINGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
F.L. Black e P.W. Hedrick, "STRONG BALANCING SELECTION AT HLA LOCI - EVIDENCE FROM SEGREGATION INSOUTH AMERINDIAN FAMILIES", Proceedings of the National Academy of Sciences of the United Statesof America, 94(23), 1997, pp. 12452-12456

Abstract

The genotypic proportions for major histocompatibility complex loci, HLA-A and HLA-B, of progeny in families in 23 South Amerindian tribes in which segregation for homozygotes and heterozygotes could occur areexamined, Overall, there is a large deficiency of homozygotes compared with Mendelian expectations (for HLA-A, 114 observed and 155.50 expected and for HLA-B 110 observed and 144.75 expected), consistent with strong balancing selection favoring heterozygotes, There is no evidence that these deficiencies were associated with particular alleles or with the age of the individuals sampled, When these families were divided into four mating types, there was strong selection against homozygotes, averaging 0.462 for three of the mating types over the two loci, For the other mating type in which the female parent is homozygous andshares one allele with the heterozygous male parent, there was no evidence of selection against homozygotes, A theoretical model incorporating these findings surprisingly does not result in a stable polymorphism for two alleles but does result in an excess of heterozygotes and aminimum fitness at intermediate allele frequencies, However, for morethan two alleles, balancing selection does occur and the model approaches the qualities of the symmetrical het erozygote advantage model asthe number of alleles increases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:18:17