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Titolo:
REGIONAL AND CELLULAR-DISTRIBUTION OF SEROTONIN 5-HYDROXYTRYPTAMINE(2A) RECEPTOR MESSENGER-RNA IN THE NUCLEUS-ACCUMBENS, OLFACTORY TUBERCLE, AND CAUDATE-PUTAMEN OF THE RAT
Autore:
MIJNSTER MJ; RAIMUNDO AGV; KOSKUBA K; KLOP H; DOCTER GJ; GROENEWEGEN HJ; VOORN P;
Indirizzi:
FREE UNIV AMSTERDAM,FAC MED,DEPT ANAT & EMBRYOL,NEUROSCI RES INST,GRAD SCH NEUROSCI AMSTERDAM NL-1081 BT AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,FAC MED,DEPT ANAT & EMBRYOL,NEUROSCI RES INST,GRAD SCH NEUROSCI AMSTERDAM NL-1081 BT AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 389, anno: 1997,
pagine: 1 - 11
SICI:
0021-9967(1997)389:1<1:RACOS5>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MESSENGER-RNA; VENTRAL STRIATUM; BASAL GANGLIA; PHARMACOLOGICAL CHARACTERIZATION; PROJECTION PATTERNS; DOPAMINE RELEASE; 5-HT2 RECEPTOR; BINDING-SITES; BRAIN;
Keywords:
STRIATUM; ENKEPHALIN; DYNORPHIN; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Mijnster et al., "REGIONAL AND CELLULAR-DISTRIBUTION OF SEROTONIN 5-HYDROXYTRYPTAMINE(2A) RECEPTOR MESSENGER-RNA IN THE NUCLEUS-ACCUMBENS, OLFACTORY TUBERCLE, AND CAUDATE-PUTAMEN OF THE RAT", Journal of comparative neurology, 389(1), 1997, pp. 1-11

Abstract

This paper describes the regional and cellular distribution of serotonin 5-hydroxytryptamine(2a) (5-HT2a) receptor mRNA in (sub)regions of the rat striatum by using in situ hybridization. Our results indicate that 5-HT2a mRNA is distributed heterogeneously in this brain region. Regional densitometry of autoradiograms from striatal sections hybridized with isotope-labeled cRNA probes showed that mRNA levels were highest in the olfactory tubercle, lower in the nucleus accumbens, and lowest in the caudate-putamen. In the nucleus accumbens, the average mRNAlevels in the shell were higher than those in the core. These data suggest a particular relevance for the 5-HT2a receptor for olfactory tubercle-and shell-related functions. Therefore, in the nucleus accumbensand the olfactory tubercle, the cellular localization of 5-HT2a mRNA was investigated by determining the colocalization of 5-HT2a mRNA withenkephalin mRNA or dynorphin mRNA. 5-HT2a mRNA was found in enkephalinergic as well as dynorphinergic neurons. Thus, there does not seem tobe a differential distribution of this receptor in the output routes of the ventral striatum. In all of the subregions investigated (core, medial shell, and lateral shell of the nucleus accumbens and the olfactory tubercle), only subpopulations of the total enkephalinergic and dynorphinergic populations were found to contain 5-HT2a mRNA. For enkephalin, the percentage colocalization was higher in the lateral shell (61%) compared with the other subregions (38-45%). For dynorphin, the percentage colocalization was higher in the olfactory tubercle (68%) than in the other subregions (34-43%). The differences in (sub)regional mRNA levels and in colocalization with opioids suggest a considerable regional differentiation in the effects of 5-HT2a mediated neurotransmission in the striatum. (C) 1997 Wiley-Liss, Inc.

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Documento generato il 20/01/20 alle ore 15:57:20