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Titolo:
SUBSTANTIAL CARDIAC PARASYMPATHETIC ACTIVITY EXISTS DURING HEAVY DYNAMIC EXERCISE IN DOGS
Autore:
OLEARY DS; ROSSI NF; CHURCHILL PC;
Indirizzi:
WAYNE STATE UNIV,SCH MED,DEPT PHYSIOL,540 E CANFIELD AVE DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DEPT INTERNAL MED DETROIT MI 48201 VET AFFAIRS MED CTR DETROIT MI 48201
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 42, anno: 1997,
pagine: 2135 - 2140
SICI:
0363-6135(1997)42:5<2135:SCPAED>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; MUSCLE METABOREFLEX CONTROL; HEART-RATE; CAROTID BAROREFLEX; AUTONOMIC MECHANISMS; ARTERIAL-PRESSURE; STATIC EXERCISE; BLOOD-PRESSURE; CONSCIOUS DOGS; RENIN-ACTIVITY;
Keywords:
MUSCLE BLOOD FLOW; ARTERIAL BLOOD PRESSURE; SYMPATHETIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; VASOPRESSIN; RENIN; OXYGEN CONSUMPTION; AUTONOMIC NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Oleary et al., "SUBSTANTIAL CARDIAC PARASYMPATHETIC ACTIVITY EXISTS DURING HEAVY DYNAMIC EXERCISE IN DOGS", American journal of physiology. Heart and circulatory physiology, 42(5), 1997, pp. 2135-2140

Abstract

We investigated the extent of functional parasympathetic and sympathetic activity to the heart at rest and during mild to heavy dynamic exercise in conscious dogs. The animals were chronically instrumented to monitor mean arterial pressure (MAP), heart rate (HR), and terminal aortic blood how (TAQ) and trained to run on a motor-driven treadmill. MAP, HR, and TAQ were monitored at rest and during steady-state dynamicexercise ranging from mild [3.2 kilometers per hour (kph), 0% grade] to heavy exercise (8 kph, 15% grade). Experiments were performed before and after blocking the effects of either the parasympathetic nerves (atropine 0.2 mg/kg iv) or sympathetic nerves (atenolol 2.0 mg/kg iv) to the heart. In addition, blood samples were taken at rest and at steady state during exercise, and plasma levels of vasopressin and renin activity were assessed. At rest and during all levels of exercise, muscarinic cholinergic receptor blockade caused a marked increase in HR over control (saline treated) levels with Little effect on MAP or TAQ. beta-Adrenergic receptor blockade had no significant effect on HR at rest and during mild exercise. At moderate to heavy workloads, beta-receptor blockade significantly reduced MAP, HR, and TAQ and increased plasma vasopressin levels. We conclude that, even during heavy dynamic exercise, significant functional parasympathetic tone to the heart exists. Thus, over a wide range of exercise workloads, HR is under the tonic control of both sympathetic and parasympathetic nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:11:44